Prominent clinical dimension, duration of illness and treatment response in schizophrenia: A naturalistic study

Massimiliano Buoli, Alice Caldiroli, Gabriele Panza, Alfredo Carlo Altamura

Research output: Contribution to journalArticlepeer-review


Objective: Preliminary data indicate that predominant positive symptoms are predictive of subsequent treatment response, while negative and cognitive symptoms are associated with poor outcome. Purpose of the present study was to investigate the relation between the predominant clinical dimension, duration of illness and acute antipsychotic response in a sample of schizophrenic inpatients. Methods: Fifty-one schizophrenic inpatients, receiving an antipsychotic mono-therapy, were dimensionally assessed at the admission in the Acute Psychiatric Unit of the University of Milan. Treatment response was selected as parameter of outcome and defined as a reduction >50% of baseline total The Positive and Negative Syndrome Scale (PANSS) score. Demographic and clinical variables between responders and non-responders were compared using one-way analysis of variance for continuous variables and χ2 test for dichotomous ones. Binary logistic regression was performed to find if dimensional scores and duration of illness were associated with acute antipsychotic response. Results: A longer duration of illness was found in non-responders respect to responders (15.61 years vs. 8.28 years)(F=4.98, p=0.03). Higher scores on PANSS positive sub-scale (OR=1.3, p=0.03), lower scores on cognitive PANSS scores (OR=0.75, p=0.05) and shorter duration of illness (OR=0.93, p=0.04) were found to be predictive of acute antipsychotic response. Conclusion: These preliminary results show that a long duration of illness as well as a more severe cognitive impairment is predictive of treatment non-response, indicating a worse outcome for chronic patients with predominant cognitive symptoms.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalPsychiatry Investigation
Issue number1
Publication statusPublished - Mar 2013


  • Antipsychotic response
  • Clinical dimensions
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Prominent clinical dimension, duration of illness and treatment response in schizophrenia: A naturalistic study'. Together they form a unique fingerprint.

Cite this