Promises and drawbacks of targeting cell cycle kinases in cancer.

Francesca Pentimalli, Antonio Giordano

Research output: Contribution to journalArticlepeer-review


The loss of ability in controlling cell cycle leads to aberrant cell growth and is a hallmark of cancer cells. Cell cycle regulation and progression mainly rely on protein phosphorylation events, therefore cell cycle kinases have long been viewed as potential targets for anticancer strategies. Consistently, cell cycle kinases are often dysregulated in different types of human cancer. Despite years of research and attempts directed at inhibiting cell cycle kinases, none of these approaches has been successfully translated to the clinic to halt tumorigenesis. Here, we review several currently pursued strategies and highlight both current challenges and some recent findings, which might help to develop new, better conceived therapeutic approaches based on cell-cycle kinase inhibition.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalDiscovery medicine
Issue number43
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Medicine(all)


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