Promising colorectal cancer biomarkers for precision prevention and therapy

Mimmo Turano, Paolo Delrio, Daniela Rega, Francesca Cammarota, Alessia Polverino, Francesca Duraturo, Paola Izzo, Marina De Rosa

Research output: Contribution to journalReview articlepeer-review

Abstract

Colorectal cancer (CRC) has been ranked as the third most prevalent cancer worldwide. Indeed, it represents 10.2% of all cancer cases. It is also the second most common cause of cancer mortality, and accounted for about 9.2% of all cancer deaths in 2018. Early detection together with a correct diagnosis and staging remains the most e_ective clinical strategy in terms of disease recovery. Thanks to advances in diagnostic techniques, and improvements of surgical adjuvant and palliative therapies, the mortality rate of CRC has decreased by more than 20% in the last decade. Cancer biomarkers for the early detection of CRC, its management, treatment and follow-up have contributed to the decrease in CRC mortality. Herein, we provide an overview of molecular biomarkers from tumor tissues and liquid biopsies that are approved for use in the CRC clinical setting for early detection, follow-up, and precision therapy, and of biomarkers that have not yet been o_cially validated and are, nowadays, under investigation.

Original languageEnglish
Article number1932
JournalCancers
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Cancer prevention
  • Colorectal cancer
  • Early cancer detection
  • Molecular biomarkers
  • Precision therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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