Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

Clinical and immunopathological evidence support a potential role of the pro- and anti-inflammatory cytokine network in neurodegeneration of Alzheimer's disease (AD). Moreover, association studies suggest a possible involvement of cytokine-related genes in the susceptibility to sporadic AD. Since conflicting results are associated with the pro-inflammatory pathway, we investigated a putative effect of the anti-inflammatory counterpart focusing on the interleukin-10 (IL-10) gene. The 5′ flanking region contains numerous polymorphisms; in particular, three single nucleotide polymorphisms (-1082 G/A, -819 T/C, -592 C/A) are in linkage disequilibrium resulting in three haplotypes GCC, ACC and ATA. We analyzed the IL-10 haplotype distributions in 215 Italian sporadic AD patients and 153 controls in an association case-control study. Haplotype frequencies did not reveal differences between the two samples, however the genotype GCC/ACC was more represented in AD patients (OR 1.91, 95% CI: 1.18-3.07). This putative risk factor could be independent of the presence of the ApoE ε4 allele. Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalNeuroscience Letters
Volume356
Issue number2
DOIs
Publication statusPublished - Feb 12 2004

Keywords

  • Alzheimer
  • Association study
  • Cytokine
  • Haplotype
  • Inflammation
  • Interleukin-10
  • Polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

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