Promyelocytic sarcoma of the spine: A case report and review of the literature

Leonardo Pacilli, Francesco Lo Coco, Safaa Mahmoud Ramadan, Laura Giann, Alberto Pingi, Daniele Remotti, Ignazio Majolino

Research output: Contribution to journalArticlepeer-review


Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.

Original languageEnglish
Article number137608
JournalAdvances in Hematology
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Hematology


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