TY - JOUR
T1 - Promyelocytic sarcoma of the spine
T2 - A case report and review of the literature
AU - Pacilli, Leonardo
AU - Lo Coco, Francesco
AU - Ramadan, Safaa Mahmoud
AU - Giann, Laura
AU - Pingi, Alberto
AU - Remotti, Daniele
AU - Majolino, Ignazio
PY - 2010
Y1 - 2010
N2 - Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.
AB - Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.
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U2 - 10.1155/2010/137608
DO - 10.1155/2010/137608
M3 - Article
C2 - 20339529
AN - SCOPUS:77954618207
VL - 2010
JO - Advances in Hematology
JF - Advances in Hematology
SN - 1687-9104
M1 - 137608
ER -