Pronounced structural and functional damage in early adult pediatric-onset multiple sclerosis with no or minimal clinical disability

Antonio Giorgio, Jian Zhang, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Lucia Nichelli, Marzia Mortilla, Emilio Portaccio, Bahia Hakiki, Maria Pia Amato, Nicola De Stefano

Research output: Contribution to journalArticle

Abstract

Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during a period of active maturation of the human brain. Whereas adaptive mechanisms seem to take place in the POMS brain in the short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at a significantly younger age than adult-onset MS (AOMS) patients. We tested for the first time whether significant brain alterations already occurred in POMS patients in their early adulthood and with no or minimal disability (n = 15) in comparison with age- and disability-matched AOMS patients (n = 14) and to normal controls (NC, n = 20). We used a multimodal MRI approach by modeling, using FSL, voxelwise measures of microstructural integrity of white matter tracts and gray matter volumes with those of intra- and internetwork functional connectivity (FC) (analysis of variance, p ≤ 0.01, corrected for multiple comparisons across space). POMS patients showed, when compared with both NC and AOMS patients, altered measures of diffusion tensor imaging (reduced fractional anisotropy and/or increased diffusivities) and higher probability of lesion occurrence in a clinically eloquent region for physical disability such as the posterior corona radiata. In addition, POMS patients showed, compared with the other two groups, reduced long-range FC, assessed from resting functional MRI, between default mode network and secondary visual network, whose interaction subserves important cognitive functions such as spatial attention and visual learning. Overall, this pattern of structural damage and brain connectivity disruption in early adult POMS patients with no or minimal clinical disability might explain their unfavorable clinical outcome in the long term.

Original languageEnglish
Article number608
JournalFrontiers in Neurology
Volume8
Issue numberNOV
DOIs
Publication statusPublished - Nov 14 2017

Keywords

  • Atrophy
  • Connectivity
  • Diffusion tensor imaging
  • Disability
  • MRI
  • Multiple sclerosis
  • Resting state networks

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Giorgio, A., Zhang, J., Stromillo, M. L., Rossi, F., Battaglini, M., Nichelli, L., Mortilla, M., Portaccio, E., Hakiki, B., Amato, M. P., & De Stefano, N. (2017). Pronounced structural and functional damage in early adult pediatric-onset multiple sclerosis with no or minimal clinical disability. Frontiers in Neurology, 8(NOV), [608]. https://doi.org/10.3389/fneur.2017.00608