Proopiomelanocortin-derived peptides and cytokines: Relations in patients with acquired immunodeficiency syndrome

A. Catania, L. Airaghi, M. G. Manfredi, M. C. Vivirito, F. Milazzo, J. M. Lipton, C. Zanussi

Research output: Contribution to journalArticle

Abstract

α-Melanocyte-stimulating hormone (α-MSH), adrenocorticotropic hormone (ACTH), β-endorphin, cortisol, and the cytokines interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNFα) were measured in 80 AIDS patients (group IV CDC) and in healthy hospital personnel. The average plasma α-MSH was significantly greater in AIDS patients than in control subjects; no significant differences between groups were observed in the average concentrations of ACTH, cortisol, and β-endorphin; plasma cytokines were likewise similar in the two groups. Plasma concentrations of α-MSH and ACTH were inversely related in AIDS patients and a similar inverse relation between α-MSH and IL-6 was also observed in these patients. There were positive relations among elevated circulating ACTH, cortisol, IL-6, and high fever in AIDS patients with severe concomitant disease. Plasma α-MSH concentrations within a specific range correlated positively with 6 month survival. Because cytokines can stimulate HIV expression in certain cell types and they are believed to have a role in disease progression in HIV-infected patients, it may be that a potent endogenous modulator of cytokine action such as α-MSH is crucial to survival in these patients.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalClinical Immunology and Immunopathology
Volume66
Issue number1
DOIs
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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