Propagation of a transmissible cytotoxic activity on cultures of human peripheral blood lymphocytes

Marinella Portolani, Francesca Beretti, Anna M. Bartoletti, Paola Pietrosemoli, Stefano Salvioli, Claudio Franceschi, Paola Sena, Anto De Pol

Research output: Contribution to journalArticle

Abstract

Positive results were attained when human peripheral blood lymphocytes (PBLs) were investigated for their ability to propagate a transmissible cytotoxic activity (TCA) isolated on VERO cell cultures from a sample of cerebrospinal fluid (CSF) drawn from a woman with ischemic brain injury. In consideration of this finding it can be assumed that "in vivo" blood lymphocytes contributed to give rise to the TCA detected "in vitro" in the CSF inoculum.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalNew Microbiologica
Volume31
Issue number3
Publication statusPublished - Jul 2008

Keywords

  • Human preripheral blood lymphocytes
  • Misfolded proteins
  • Transmissible cytotoxicity

ASJC Scopus subject areas

  • Microbiology (medical)

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  • Cite this

    Portolani, M., Beretti, F., Bartoletti, A. M., Pietrosemoli, P., Salvioli, S., Franceschi, C., Sena, P., & De Pol, A. (2008). Propagation of a transmissible cytotoxic activity on cultures of human peripheral blood lymphocytes. New Microbiologica, 31(3), 417-422.