Properties of a glycopeptide isolated from human Tamm-Horsfall glycoprotein. Interaction with leucoagglutinin and anti-(human Tamm-Horsfall glycoprotein) antibodies

A. Abbondanza, C. Franceschi, F. Licastro, F. Serafini-Cessi

Research output: Contribution to journalArticle

Abstract

A sialylated glycopeptide isolated after Pronase digestion of human Tamm-Horsfall glycoprotein behaves as a powerful monovalent hapten in the precipitin reaction between human Tamm-Horsfall glycoprotein and leucoagglutinin, but fails to inhibit the interaction of the glycoprotein with rabbit anti-(human Tamm-Horsfall glycoprotein) antibodies. The glycopeptide is much less active than the intact glycoprotein as an inhibitor of lymphocyte transformation induced by leucoagglutinin.

Original languageEnglish
Pages (from-to)525-528)
JournalBiochemical Journal
Volume187
Issue number2
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Biochemistry

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