Properties of the spike afterhyperpolarization in pyramidal tract neurons

Fausto Baldissera, Paola Campadelli, Enrica Fava, Lino Piccinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Features of the spike afterhyperpolarization (AHP) recorded intracellularly have been analyzed in fast pyramidal tract neurons of cats. Cell input conductance increases during the AHP, possibly because of a change in potassium conductance, as suggested by an AHP equilibrium potential 10-15 mV negative to the resting membrane potential. When more spikes are evoked in succession, AHPs following the first one are strongly reduced in amplitude. The effect is virtually maximal (30-50% of the control) after a single spike and fades out by 200-400 ms after the last spike. At short interspike intervals the initial time course of the depression is hidden by summation occurring between consecutive AHPs.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalBrain Research
Volume259
Issue number1
DOIs
Publication statusPublished - Jan 17 1983

Keywords

  • afterhyperpolarization
  • intracellular recording
  • potassium conductance
  • pyramidal tract neurons

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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