Profilassi della tossicita sul sistema venoso periferico associata alla somministrazione endovenosa di vinorelbine

Translated title of the contribution: Prophilaxis of venous side effects associated with vinorelbine administration

S. Cinieri, L. Orland, E. Cocorocchio, E. Munzone, C. Catania, C. Brunetti, A. Rocca, G. Martinelli, F. Nole

Research output: Contribution to journalArticlepeer-review


Vinorelbine is effective in the treatment of a number of malignancies. However, beside the haematologic and not haematologic toxicity as thrombocytopenia, granulocytopenia, fatigue, paresthesias, nausea and vomiting, one of the most common side effects is the local irritation with thrombophlebitis. The side effect, reported in about 10-26% of patients receiving vinorelbine infusions, is due to the vessicant and irritant action of the drug. Many studies have been performed in order to reduce the incidence of venous irritation either with concomitant administration of anti-inflammatory drugs as defibrotide or ketorolac, or changing infusion schedule from bolus infusion to a 20-30 minute infusion. Aim of this review is to define peripheral venous system toxicity of vinorelbine and the best way of administration.

Translated title of the contributionProphilaxis of venous side effects associated with vinorelbine administration
Original languageItalian
Pages (from-to)225-229
Number of pages5
JournalClinica Terapeutica
Issue number3
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Medicine(all)


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