TY - JOUR
T1 - Prophylactic immunosuppression with anti-interleukin-2 receptor monoclonal antibody LO-Tact-1 versus OKT3 in liver allografting. A two-year follow-up study
AU - Reding, Raymond
AU - Feyaerts, Axel
AU - Vraux, Hubert
AU - Latinne, Dominique
AU - De La Parra, Bernardo
AU - Cornet, Anne
AU - Cormont, Françoise
AU - Jamart, Jacques
AU - Sokal, Etienne
AU - De Ville De Goyet, Jean
AU - Lerut, Jan
AU - Bazin, Hervé
AU - Otte, Jean Bernard
PY - 1996/5/15
Y1 - 1996/5/15
N2 - A prospective trial was conducted in 129 recipients of primary liver transplantation, to compare induction immunosuppression using triple drug therapy (cyclosporine, steroids, and azathioprine; group 1, n=42), versus triple drug therapy with a 10-day course of OKT3 (group 2, n=44) or of the anti-interleukin-2 receptor monoclonal antibody LO-Tact-1 (group 3, n=43). Two-year actual patient survival rates were 64%, 79%, and 93% in groups 1, 2, and 3, respectively (1 vs. 2, NS; I vs. III, P=0.003; 2 vs. 3, NS). Up to 2 years after transplantation, 18%, 44%, and 53% of the grafts in groups 1, 2, and 3, respectively, had not experienced steroid-resistant acute rejection (1 vs. 2, P=0.002; 1 vs. 3, P=0.007; 2 vs. 3, NS). The overall incidence of chronic rejection was 4%. OKT3 therapy, but not LO-Tact-1, significantly increased the incidence of cytomegalovirus infections (P=0.019). In conclusion, immunoprophylaxis with LO-Tact-1 seemed to provide a liver graft acceptance rate at least as satisfactory as that with OKT3, without an increase in the incidence of infections.
AB - A prospective trial was conducted in 129 recipients of primary liver transplantation, to compare induction immunosuppression using triple drug therapy (cyclosporine, steroids, and azathioprine; group 1, n=42), versus triple drug therapy with a 10-day course of OKT3 (group 2, n=44) or of the anti-interleukin-2 receptor monoclonal antibody LO-Tact-1 (group 3, n=43). Two-year actual patient survival rates were 64%, 79%, and 93% in groups 1, 2, and 3, respectively (1 vs. 2, NS; I vs. III, P=0.003; 2 vs. 3, NS). Up to 2 years after transplantation, 18%, 44%, and 53% of the grafts in groups 1, 2, and 3, respectively, had not experienced steroid-resistant acute rejection (1 vs. 2, P=0.002; 1 vs. 3, P=0.007; 2 vs. 3, NS). The overall incidence of chronic rejection was 4%. OKT3 therapy, but not LO-Tact-1, significantly increased the incidence of cytomegalovirus infections (P=0.019). In conclusion, immunoprophylaxis with LO-Tact-1 seemed to provide a liver graft acceptance rate at least as satisfactory as that with OKT3, without an increase in the incidence of infections.
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M3 - Article
C2 - 8629306
AN - SCOPUS:0029878231
VL - 61
SP - 1406
EP - 1409
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 9
ER -