Prophylactic or early selective surfactant combined with nCPAP in very preterm infants

Fabrizio Sandri, Richard Plavk, Gina Ancor, Umberto Simeoni, Zbyněk Stranak, Stefano Martinelli, Fabio Mosca, José Nona, Merran Thomson, Henrik Verder, Laura Fabbri, Henry Halliday

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Early surfactant followed by extubation to nasal continuous positive airway pressure (nCPAP) compared with later surfactant and mechanical ventilation (MV) reduce the need for MV, air leaks, and bronchopulmonary dysplasia. This randomized, controlled trial investigated whether prophylactic surfactant followed by nCPAP compared with early nCPAP application with early selective surfactant would reduce the need for MV in the first 5 days of life. METHODS: A total of 208 inborn infants who were born at 25 to 28 weeks' gestation and were not intubated at birth were randomly assigned to prophylactic surfactant or nCPAP within 30 minutes of birth. Outcomes were assessed within the first 5 days of life and until death or discharge of the infants from hospital. RESULTS: Thirty-three (31.4%) infants in the prophylactic surfactant group needed MV in the first 5 days of life compared with 34 (33.0%) in the nCPAP group (risk ratio: 0.95 [95% confidence interval: 0.64-1.41]; P = .80). Death and type of survival at 28 days of life and 36 weeks' postmenstrual age and incidence of main morbidities of prematurity (secondary outcomes) were similar in the 2 groups. A total of 78.1% of infants in the prophylactic surfactant group and 78.6% in the nCPAP group survived in room air at 36 weeks' postmenstrual age. CONCLUSIONS: Prophylactic surfactant was not superior to nCPAP and early selective surfactant in decreasing the need for MV in the first 5 days of life and the incidence of main morbidities of prematurity in spontaneously breathing very preterm infants on nCPAP.

Original languageEnglish
JournalPediatrics
Volume125
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Bronchopulmonary dysplasia
  • Mechanical ventilation
  • nCPAP
  • Preterm newborn
  • Respiratory distress syndrome
  • Surfactant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Sandri, F., Plavk, R., Ancor, G., Simeoni, U., Stranak, Z., Martinelli, S., Mosca, F., Nona, J., Thomson, M., Verder, H., Fabbri, L., & Halliday, H. (2010). Prophylactic or early selective surfactant combined with nCPAP in very preterm infants. Pediatrics, 125(6). https://doi.org/10.1542/peds.2009-2131