Sclérothérapie prophylactique des varices œsophagiennes à haut risque de saignement etude prospective et randomisée, avec longue période de surveillance

Translated title of the contribution: Prophylactic sclerotherapy of esophageal high bleeding risk varices a prospective randomized trial, with a long follow-up

S. Rossi, F. Fornari, P. Tansini, M. Di stasi, G. Sbolli, E. Buscarini, L. Cavanna, G. Civardi, L. Buscarini

Research output: Contribution to journalArticle


The efficacy of prophylactic sclerotherapy of varices at high risk of bleeding in cirrhotic patients with spared clotting function before the first episode of variceal haemorrhage, was evaluated in a prospective, randomized, controlled trial. 37 patients were treated as followed : 18 patients received prophylactic sclerotherapy and 19 served as controls. The median follow-up was 36.6 months. The mortality rate due to bleeding during the overall observation period was significantly lower in the sclerotherapy group versus control group (P = 0.003). Life table curves showed that prophylactic sclerotherapy significantly diminished the incidence of variceal haemorrhage (P = 0.02) and significantly improved overall survival (P = 0.009). We concluded that prophylactic sclerotherapy is useful in the treatment of cirrhotic patients with high-risk bleeding varices and spared clotting function.

Original languageFrench
Pages (from-to)463-472
Number of pages10
JournalActa Endoscopica
Issue number3
Publication statusPublished - May 1991



  • digestive haemorrhage
  • esophageal varices
  • prophylactic
  • sclerotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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