Prophylactic single-dose prulifloxacin for catheter-associated urinary tract infection after tension-free vaginal tape procedure

Fabio Ghezzi, Maurizio Serati, Antonella Cromi, Stefano Uccella, Stefano Salvatore, Pierfrancesco Bolis

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the study was to evaluate whether antibiotic prophylaxis with a single dose of prulifloxacin after tension-free vaginal tape (TVT) procedure decreases catheter-associated urinary tract infections (UTIs). Patients undergoing TVT procedure receiving a single dose of prulifloxacin (600 mg) 10 h before catheter removal (n=54) were compared with historical controls who have had no treatment (n=60). All patients had an indwelling urethral catheter in situ for 24 h. Urine specimens for culture were collected preoperatively, before Foley removal, and 7 days postoperatively in both groups. Main outcome measures were significant bacteriuria and symptomatic UTI at catheter removal and 1 week postoperatively. No patient had a positive urine culture in the prulifloxacin group compared with 14 (23.3%) in the control group at catheter removal (P=0.0001). Ten out of 14 (71.4%) women with a positive catheter urine culture had a symptomatic UTI. One week after surgery no difference was found in the rate of significant bacteriuria between groups. Our data suggest that a prophylactic single dose of prulifloxacin could help to reduce the rate of symptomatic and asymptomatic UTIs after short-term urethral catheterization in women undergoing TVT procedure.

Original languageEnglish
Pages (from-to)753-757
Number of pages5
JournalInternational Urogynecology Journal and Pelvic Floor Dysfunction
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Antibiotic prophylaxis
  • Catheter-associated urinary tract infections
  • Prulifloxacin
  • Tension-free vaginal tape

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology

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