Terapia profilattica per l'epilessia post-traumatica nel trauma cranico grave

Translated title of the contribution: Prophylactic therapy for post-traumatic epilepsy in severe brain injury

R. Formisano, F. Spanedda, P. Bianchi, F. Penta, D. Mattia, M. G. Marciani

Research output: Contribution to journalArticlepeer-review


Although many authors recommend the utilization of anti-epileptic drugs for the prevention of post-traumatic epilepsy, some controlled studies have demonstrated a lack of efficacy of prophylactic treatment. The aim of this retrospective study conducted on a population of severe brain-injured patients, was to assess the incidence of post-traumatic epilepsy depending on whether patients have or have not received preventive treatment. We studied 55 patients suffering from severe brain injury (43 M, 12 F) with a disturbance of consciousness lasting longer than 2 weeks, admitted to our rehabilitation hospital from January 1992 to January 1993. Ten out of the 55 patients studied (18%) suffered from post-traumatic epilepsy. The incidence of epilepsy (at least 2 years after the brain injury) was lower in patients not given prophylactic treatment than in patients treated with preventive antiepileptic therapy (29% versus 13%), though the difference between the 2 groups was not statistically significant. Since anti-epileptic drugs may reduce vigilance and cognition, confirmations of these data in larger series of patients may be of considerable interest.

Translated title of the contributionProphylactic therapy for post-traumatic epilepsy in severe brain injury
Original languageItalian
Pages (from-to)305-307
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number99
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology


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