Abstract
Germline mutation of the CDH1 gene, which encodes for the E-cadherin adhesion protein, is rare but confers an estimated lifetime risk of hereditary diffuse gastric cancer higher than 80 %. Prophylactic total gastrectomy seems to eliminate the high risk of developing diffuse gastric cancer in patients with this mutation. Current guidelines propose an accurate pre-operative work-up to engage patients at risk who can be good candidates for prophylactic surgery. In this chapter we analyze the general indications to prophylactic total gastrectomy and the diagnostic and therapeutic work-up, with particular reference to the techniques most used and recommended. We also investigate the metabolic consequences of a total gastrectomy and its impact on the patient's quality of life, together with the possible complications can be caused by this kind of operation.
Original language | English |
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Title of host publication | Spotlight on Familial and Hereditary Gastric Cancer |
Publisher | Springer Netherlands |
Pages | 167-176 |
Number of pages | 10 |
ISBN (Print) | 9789400765702, 940076569X, 9789400765696 |
DOIs | |
Publication status | Published - Feb 1 2013 |
Keywords
- E-cadherin mutation
- Familial gastric cancer
- Hereditary gastric cancer
- Prophylactic total gastrectomy
ASJC Scopus subject areas
- Medicine(all)