Prophylactic total gastrectomy in CDH1 germline mutation carriers

Francesco Ferrara, Giovanni Corso, Franco Roviello

Research output: Chapter in Book/Report/Conference proceedingChapter


Germline mutation of the CDH1 gene, which encodes for the E-cadherin adhesion protein, is rare but confers an estimated lifetime risk of hereditary diffuse gastric cancer higher than 80 %. Prophylactic total gastrectomy seems to eliminate the high risk of developing diffuse gastric cancer in patients with this mutation. Current guidelines propose an accurate pre-operative work-up to engage patients at risk who can be good candidates for prophylactic surgery. In this chapter we analyze the general indications to prophylactic total gastrectomy and the diagnostic and therapeutic work-up, with particular reference to the techniques most used and recommended. We also investigate the metabolic consequences of a total gastrectomy and its impact on the patient's quality of life, together with the possible complications can be caused by this kind of operation.

Original languageEnglish
Title of host publicationSpotlight on Familial and Hereditary Gastric Cancer
PublisherSpringer Netherlands
Number of pages10
ISBN (Print)9789400765702, 940076569X, 9789400765696
Publication statusPublished - Feb 1 2013


  • E-cadherin mutation
  • Familial gastric cancer
  • Hereditary gastric cancer
  • Prophylactic total gastrectomy

ASJC Scopus subject areas

  • Medicine(all)


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