Prophylactic treatment with melatonin after status epilepticus: Effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy

Jana Tchekalarova, Zlatina Petkova, Daniela Pechlivanova, Slavianka Moyanova, Lidia Kortenska, Rumiana Mitreva, Valentin Lozanov, Dimitrina Atanasova, Nikolai Lazarov, Alexander Stoynev

Research output: Contribution to journalArticle

Abstract

Melatonin is a potent antioxidant which showed anticonvulsant activities both in experimental and clinical studies. In the present study, we examined the effect of melatonin treatment (10. mg/kg/day, diluted in drinking water, 8. weeks) during epileptogenesis on the consequences of a kainate (KA)-induced status epilepticus (SE) in rats. Melatonin increased the latency in the appearance of spontaneous recurrent seizures (SRSs) and decreased their frequency only during the treatment period. The behavioral alterations associated with hyperactivity, depression-like behavior during the light phase, and deficits in hippocampus-dependent working memory were positively affected by melatonin treatment in rats with epilepsy. Melatonin reduced the neuronal damage in the CA1 area of the hippocampus and piriform cortex and recovered the decrease of hippocampal serotonin (5-HT) level in rats with epilepsy. Taken together, long-term melatonin treatment after SE was unable to suppress the development of epileptogenesis. However, it showed a potential in reducing some of the deleterious alterations that develop during the chronic epileptic state in a diurnal phase-dependent mode.

Original languageEnglish
Pages (from-to)174-187
Number of pages14
JournalEpilepsy and Behavior
Volume27
Issue number1
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Circadian
  • Depression
  • Kainic acid
  • Melatonin
  • Monoamines
  • Neuronal damage

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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  • Cite this

    Tchekalarova, J., Petkova, Z., Pechlivanova, D., Moyanova, S., Kortenska, L., Mitreva, R., Lozanov, V., Atanasova, D., Lazarov, N., & Stoynev, A. (2013). Prophylactic treatment with melatonin after status epilepticus: Effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. Epilepsy and Behavior, 27(1), 174-187. https://doi.org/10.1016/j.yebeh.2013.01.009