Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation a randomized clinical trial

Flavia Indrio, Antonio Di Mauro, Giuseppe Riezzo, Elisa Civardi, Cristina Intini, Luigi Corvaglia, Elisa Ballardini, Massimo Bisceglia, Mauro Cinquetti, Emanuela Brazzoduro, Antonio Del Vecchio, Silvio Tafuri, Ruggiero Francavilla

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety, and loss of parental working days with relevant social consequences. OBJECTIVE: To investigate whether oral supplementation with Lactobacillus reuteri DSM 17938 during the first 3 months of life can reduce the onset of colic, gastroesophageal reflux, and constipation in term newborns and thereby reduce the socioeconomic impact of these conditions. DESIGN: A prospective, multicenter, double-masked, placebo-controlled randomized clinical trial was performed on term newborns (age

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalJAMA Pediatrics
Volume168
Issue number3
DOIs
Publication statusPublished - Mar 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Indrio, F., Di Mauro, A., Riezzo, G., Civardi, E., Intini, C., Corvaglia, L., Ballardini, E., Bisceglia, M., Cinquetti, M., Brazzoduro, E., Del Vecchio, A., Tafuri, S., & Francavilla, R. (2014). Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation a randomized clinical trial. JAMA Pediatrics, 168(3), 228-233. https://doi.org/10.1001/jamapediatrics.2013.4367