Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial

Giovanni Montini, Luca Rigon, Pietro Zucchetta, Federica Fregonese, Antonella Toffolo, Daniela Gobber, Diego Cecchin, Luigi Pavanello, Pier Paolo Molinari, Francesca Maschio, Sergio Zanchetta, Walburga Cassar, Luca Casadio, Carlo Crivellaro, Paolo Fortunati, Andrea Corsini, Alessandro Calderan, Stefania Comacchio, Lisanna Tommasi, Ian K. HewittLiviana Da Dalt, Graziella Zacchello, Roberto Dall'Amico

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES. Febrile urinary tract infections are common in children and associated with the risk for renal scarring and long-term complications. Antimicrobial prophylaxis has been used to reduce the risk for recurrence. We performed a study to determine whether no prophylaxis is similar to antimicrobial prophylaxis for 12 months in reducing the recurrence of febrile urinary tract infections in children after a first febrile urinary tract infection. Methods. The study was a controlled, randomized, open-label, 2-armed, noninferiority trial comparing no prophylaxis with prophylaxis (co-trimoxazole 15 mg/kg per day or co-amoxiclav 15 mg/kg per day) for 12 months. A total of 338 children who were aged 2 months to

Original languageEnglish
Pages (from-to)1064-1071
Number of pages8
JournalPediatrics
Volume122
Issue number5
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Antibiotic prophylaxis
  • DMSA scan
  • Renal scar
  • Urinary tract infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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