Profilassi e trattamento della neutropenia febbrile

Translated title of the contribution: Prophylaxis and treatment in febril netropenia

Filippo Montemurro, Margherita Gallicchio, Massimo Aglietta

Research output: Contribution to journalArticlepeer-review


Many chemotherapy regimens are associated with variable periods of myelosuppression. In cancer patients, neutropenia (less than 500 neutrophils/μL) is the most important risk factor for infections. The incidence and severity of infectious complicaticns are related to depth and duration of neutropenia, with the highest risk if neutrophils are less than 100/μL for more than a week. The period required for neutrophil recovery is usually short with standard regimens, but prolonged after high dose chemotherapy followed by autologous bone marrow transplant (ABMT) or peripheral blood stem cell (PBSC) infusion. Under these conditions, the administration of granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) accelerates neutrophil recovery and shortens the duration of hospitalization. In standard chemotherapy settings, prophylactic use of CSF's is a matter of debate. Several studies have reached contrasting conclusion, but, combining effectiveness and costs, it results that this use of CSF'S is not to be recommended unless the risk of infections (elderly patients, reduced marrow reserve) is high. The administration of G-CSF or GM-CSF to a febrile neutropenic patient (cfr CSF's therapy) shortens the duration of neutropenia, although no great clinical benefits are evident. Nevertheless the identification of subsets of patients with additional risk factors (i.e. absolute neutrophil count

Translated title of the contributionProphylaxis and treatment in febril netropenia
Original languageItalian
Issue number2 SUPPL.
Publication statusPublished - Mar 1997

ASJC Scopus subject areas

  • Cancer Research


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