Prophylaxis of Recurrent Acute Otitis Media and Middle-Ear Effusion: Comparison of Amoxicillin With Sulfamethoxazole and Trimethoprim

Nicola Principi, Paola Marchisio, Emilia Massironi, Rosa Maria Grasso, Gianfranco Filiberti

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the efficacy of amoxicillin with that of the combination drug sulfamethoxazole and trimethoprim in reducing recurrences of acute otitis media (AOM) in a single-blind, randomized, placebo-controlled trial involving 96 children. Each of the children had had three or more episodes of AOM in the preceding 6 months, and 97% (93/96) of them still had unilateral or bilateral effusion at the beginning of the study. During the 6-month study period, 9 (27%) of 33 of the children in the amoxicillin group developed 9 episodes of AOM, 9(27%) of 33 of the children in the sulfamethoxazole and trimethoprim group experienced 11 episodes of AOM, and 19 (63%) of 30 of the children in the placebo group developed 25 episodes. Young age and day-care attendance characterized children for whom prophylaxis was more efficacious. Overall persistence of middle-ear effusion was shorter in treated children only as a consequence of the reduced number of new episodes of AOM.

Original languageEnglish
Pages (from-to)1414-1418
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume143
Issue number12
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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