PROFILASSI PERIOPERATORIA CON TEICOPLANINA IN PAZIENTI SOTTOPOSTE A RICOSTRUZIONE MAMMARIA CON RETTO ADDOMINALE. STUDIO CASO-CONTROLLO

Translated title of the contribution: Prophylaxis with teicoplanin in patients undergoing breast reconstruction with rectus abdominis myocutaneous flap

S. Franchelli, M. S. Leone, E. Vigna, E. Raposio, F. Cafiero, M. Costantini, R. Capuzzo, M. Gipponi, P. L. Santi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap (TRAMF). The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid. From October 1990 to March 1992 38 patients were recruited: 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group. Analysis of drainage fluids showed a higher contamination rate (15/18 = 83%) in the control group as compared to the prophylaxis arm (2/20 = 10%) (p <0.0001). Moreover, 11 patients in the control arm suffered from fever >37.5°C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group; the postoperative stay was 13.3 ± 4.3 and 9.0 ± 1.6 in the control and antibiotic arm respectively. No antibiotic related side effects were evidenced through the study. These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperativc infection in such kind of 'clean' operative procedure.

Translated title of the contributionProphylaxis with teicoplanin in patients undergoing breast reconstruction with rectus abdominis myocutaneous flap
Original languageItalian
Pages (from-to)59-63
Number of pages5
JournalMinerva Chirurgica
Volume49
Issue number1-2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Surgery

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