Abstract
The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap (TRAMF). The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid. From October 1990 to March 1992 38 patients were recruited: 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group. Analysis of drainage fluids showed a higher contamination rate (15/18 = 83%) in the control group as compared to the prophylaxis arm (2/20 = 10%) (p <0.0001). Moreover, 11 patients in the control arm suffered from fever >37.5°C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group; the postoperative stay was 13.3 ± 4.3 and 9.0 ± 1.6 in the control and antibiotic arm respectively. No antibiotic related side effects were evidenced through the study. These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperativc infection in such kind of 'clean' operative procedure.
| Original language | Italian |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | Minerva Chirurgica |
| Volume | 49 |
| Issue number | 1-2 |
| Publication status | Published - 1994 |
Fingerprint
ASJC Scopus subject areas
- Surgery
Cite this
PROFILASSI PERIOPERATORIA CON TEICOPLANINA IN PAZIENTI SOTTOPOSTE A RICOSTRUZIONE MAMMARIA CON RETTO ADDOMINALE. STUDIO CASO-CONTROLLO. / Franchelli, S.; Leone, M. S.; Vigna, E.; Raposio, E.; Cafiero, F.; Costantini, M.; Capuzzo, R.; Gipponi, M.; Santi, P. L.
In: Minerva Chirurgica, Vol. 49, No. 1-2, 1994, p. 59-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PROFILASSI PERIOPERATORIA CON TEICOPLANINA IN PAZIENTI SOTTOPOSTE A RICOSTRUZIONE MAMMARIA CON RETTO ADDOMINALE. STUDIO CASO-CONTROLLO
AU - Franchelli, S.
AU - Leone, M. S.
AU - Vigna, E.
AU - Raposio, E.
AU - Cafiero, F.
AU - Costantini, M.
AU - Capuzzo, R.
AU - Gipponi, M.
AU - Santi, P. L.
PY - 1994
Y1 - 1994
N2 - The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap (TRAMF). The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid. From October 1990 to March 1992 38 patients were recruited: 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group. Analysis of drainage fluids showed a higher contamination rate (15/18 = 83%) in the control group as compared to the prophylaxis arm (2/20 = 10%) (p <0.0001). Moreover, 11 patients in the control arm suffered from fever >37.5°C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group; the postoperative stay was 13.3 ± 4.3 and 9.0 ± 1.6 in the control and antibiotic arm respectively. No antibiotic related side effects were evidenced through the study. These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperativc infection in such kind of 'clean' operative procedure.
AB - The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap (TRAMF). The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid. From October 1990 to March 1992 38 patients were recruited: 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group. Analysis of drainage fluids showed a higher contamination rate (15/18 = 83%) in the control group as compared to the prophylaxis arm (2/20 = 10%) (p <0.0001). Moreover, 11 patients in the control arm suffered from fever >37.5°C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group; the postoperative stay was 13.3 ± 4.3 and 9.0 ± 1.6 in the control and antibiotic arm respectively. No antibiotic related side effects were evidenced through the study. These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperativc infection in such kind of 'clean' operative procedure.
KW - antibiotics, prophylaxis
KW - breast reconstruction
KW - surgical flaps, myocutaneous
UR - http://www.scopus.com/inward/record.url?scp=0028329193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028329193&partnerID=8YFLogxK
M3 - Articolo
C2 - 8208469
AN - SCOPUS:0028329193
VL - 49
SP - 59
EP - 63
JO - Minerva Chirurgica
JF - Minerva Chirurgica
SN - 0026-4733
IS - 1-2
ER -