Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-β aggregation

Maria Laura Bolognesi, Vincenza Andrisano, Manuela Bartolini, Rita Banzi, Carlo Melchiorre

Research output: Contribution to journalArticlepeer-review

Abstract

Heterodimers 4 and 5 were effective inhibitors of acetylcholinesterase (AChE) activity and AChE-induced amyloid-β (Aβ) aggregation. The peculiar biological profile of 4 can be relevant in studying the molecular basis underlying the nonclassical action of AChE and in addressing the question whether AChE inhibitors can affect the neurotoxic cascade leading to Alzheimer's disease. Compound 4 emerged as the most potent heterodimer so far available to inhibit AChE-induced Aβ aggregation.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJournal of Medicinal Chemistry
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 13 2005

ASJC Scopus subject areas

  • Organic Chemistry

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