Propofol anaesthesia in spontaneously breathing paediatric patients during magnetic resonance imaging

A. Levati, N. Colombo, E. M. Arosio, G. Savoia, C. Tommasino, G. Scialfa, L. Boselli

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to evaluate the use of propofol to induce and maintain anaesthesia in spontaneously breathing paediatric patients (age 2 weeks - 11 years) during Magnetic Resonance Imaging (MRI) of the CNS. Methods: All patients were spontaneously breathing, without intubation, and received supplemental O2. Pulse rate, blood pressure (BP), electrocardiogram and EtCO2 were recorded in all patients, and in 38 subjects SpO2 was also monitored. Patients were divided in 2 groups according to their body weights: Group A (n = 34, bwt ≤ 10 kg), and Group B (n = 48, bwt > 10 kg). Results: Dosage of propofol during the time of induction (from insertion of the i.v. cannula to positioning on the MRI table) was significantly higher in smaller children (Group A; 5.4 ± 2.2 (SD) mg/kg) as compared to children with bwt above 10 kg (Group B; 3.7 ± 1.6 mg/kg). Propofol dosage for maintenance of anaesthesia was significantly higher in smaller children (Group A: 10.1 ± 5.7 vs Group B: 7.1 ± 3.0 mg kg-1h-1, P = 0.003). During the time of induction, transient episodes of reduced BP (≤ 20%) occurred in 6 patients in Group A and 2 patients in Group B. During anaesthesia in Group B there was 1 episode of oxygen desaturation (95%), and 3 episodes of short and mild increases of EtCO2 (≤ 52 mmHg). No other side effects occurred in any patient. MRI studies were successfully completed, only 3 sequences (Group A) had to be restarted. Conclusion: Propofol can be safely used for total intravenous anaesthesia in children undergoing MRI.

Original languageEnglish
Pages (from-to)561-565
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume40
Issue number5
Publication statusPublished - 1996

Keywords

  • Anesthesia: pediatric, propofol
  • Central nervous system
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Propofol anaesthesia in spontaneously breathing paediatric patients during magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this

    Levati, A., Colombo, N., Arosio, E. M., Savoia, G., Tommasino, C., Scialfa, G., & Boselli, L. (1996). Propofol anaesthesia in spontaneously breathing paediatric patients during magnetic resonance imaging. Acta Anaesthesiologica Scandinavica, 40(5), 561-565.