Propofol Formulation Affects Myocardial Function in Newborn Infants

Anna Claudia Massolo, Stefania Sgrò, Fiammetta Piersigilli, Karel Allegaert, Irma Capolupo, Jole Rechichi, Francesca Landolfo, Flaminia Calzolari, Alessandra Toscano, Sergio Picardo, Neil Patel

Research output: Contribution to journalArticle

Abstract

This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included: nine (50%) P1% and nine (50%) Pd. In the P1% group, TDI velocities and LS were significantly reduced at t1 and t2. In the Pd Group, only TDI velocities in the left ventricle were reduced at t1, but not at t2. Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.

Original languageEnglish
JournalPediatric Cardiology
DOIs
Publication statusE-pub ahead of print - Aug 14 2019

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Propofol
Newborn Infant
Heart Ventricles
Safety

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Propofol Formulation Affects Myocardial Function in Newborn Infants. / Massolo, Anna Claudia; Sgrò, Stefania; Piersigilli, Fiammetta; Allegaert, Karel; Capolupo, Irma; Rechichi, Jole; Landolfo, Francesca; Calzolari, Flaminia; Toscano, Alessandra; Picardo, Sergio; Patel, Neil.

In: Pediatric Cardiology, 14.08.2019.

Research output: Contribution to journalArticle

Massolo, Anna Claudia ; Sgrò, Stefania ; Piersigilli, Fiammetta ; Allegaert, Karel ; Capolupo, Irma ; Rechichi, Jole ; Landolfo, Francesca ; Calzolari, Flaminia ; Toscano, Alessandra ; Picardo, Sergio ; Patel, Neil. / Propofol Formulation Affects Myocardial Function in Newborn Infants. In: Pediatric Cardiology. 2019.
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abstract = "This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1{\%} propofol (P1{\%}); and those who received a diluted formulation (Pd) of equal volumes propofol 1{\%} and 0.9{\%} NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included: nine (50{\%}) P1{\%} and nine (50{\%}) Pd. In the P1{\%} group, TDI velocities and LS were significantly reduced at t1 and t2. In the Pd Group, only TDI velocities in the left ventricle were reduced at t1, but not at t2. Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.",
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AU - Massolo, Anna Claudia

AU - Sgrò, Stefania

AU - Piersigilli, Fiammetta

AU - Allegaert, Karel

AU - Capolupo, Irma

AU - Rechichi, Jole

AU - Landolfo, Francesca

AU - Calzolari, Flaminia

AU - Toscano, Alessandra

AU - Picardo, Sergio

AU - Patel, Neil

PY - 2019/8/14

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N2 - This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included: nine (50%) P1% and nine (50%) Pd. In the P1% group, TDI velocities and LS were significantly reduced at t1 and t2. In the Pd Group, only TDI velocities in the left ventricle were reduced at t1, but not at t2. Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.

AB - This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included: nine (50%) P1% and nine (50%) Pd. In the P1% group, TDI velocities and LS were significantly reduced at t1 and t2. In the Pd Group, only TDI velocities in the left ventricle were reduced at t1, but not at t2. Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.

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