Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Luca De Sabato, Philippe Lemey, Bram Vrancken, Lebana Bonfanti, Letizia Ceglie, Gabriele Vaccari, Ilaria Di Bartolo

Research output: Contribution to journalArticle

Abstract

The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalVirus Research
Volume248
DOIs
Publication statusPublished - Mar 15 2018

Keywords

  • Complete genome
  • Genotype 3
  • Hepatitis E virus
  • Next generation sequencing
  • Subtype
  • Swine

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

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