TY - JOUR
T1 - Proposal for a tailored stratification at baseline and monitoring of cardiovascular effects during follow-up in chronic phase chronic myeloid leukemia patients treated with nilotinib frontline
AU - Breccia, Massimo
AU - Arboscello, Eleonora
AU - Bellodi, Andrea
AU - Colafigli, Gioia
AU - Molica, Matteo
AU - Bergamaschi, Micaela
AU - Massaro, Fulvio
AU - Quattrocchi, Luisa
AU - Sarocchi, Matteo
AU - Spallarossa, Paolo
AU - Alimena, Giuliana
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/11
Y1 - 2016/11
N2 - Nilotinib was approved for chronic myeloid leukemia patients in chronic phase or accelerated phase after resistance to imatinib or as frontline treatment. The drug, as other tyrosine kinase inhibitor has a specific safety profile with possible occurring metabolic side effects, such as increased glycaemia and cholesterol level, that may result, in predisposed patients, in an increased rate of cardiac and vascular disorders. The objectives of this paper were to focus on the optimal procedures to perform at diagnosis in order to identify patients at risk of possible events and the correct monitoring procedures in order to prevent and manage metabolic and cardiovascular adverse events. Several national haematologist and cardiologist reviewed the literature, analysed levels of evidence for each topic and, after extensive discussions presented their proposals based on current international guidelines.
AB - Nilotinib was approved for chronic myeloid leukemia patients in chronic phase or accelerated phase after resistance to imatinib or as frontline treatment. The drug, as other tyrosine kinase inhibitor has a specific safety profile with possible occurring metabolic side effects, such as increased glycaemia and cholesterol level, that may result, in predisposed patients, in an increased rate of cardiac and vascular disorders. The objectives of this paper were to focus on the optimal procedures to perform at diagnosis in order to identify patients at risk of possible events and the correct monitoring procedures in order to prevent and manage metabolic and cardiovascular adverse events. Several national haematologist and cardiologist reviewed the literature, analysed levels of evidence for each topic and, after extensive discussions presented their proposals based on current international guidelines.
KW - Review
KW - Journal Article
U2 - 10.1016/j.critrevonc.2016.10.002
DO - 10.1016/j.critrevonc.2016.10.002
M3 - Article
C2 - 27823647
VL - 107
SP - 190
EP - 198
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
ER -