Proposal of a 4D ML reconstruction strategy for PET-based treatment verification in ion beam radiotherapy

Elisabetta De Bernardi; Chiara Gianoli; Rosalinda Ricotti; Marco Riboldi; Guido Baroni

doi:10.1109/NSSMIC.2014.7431001

Proposal of a 4D ML reconstruction strategy for PET-based treatment verification in ion beam radiotherapy

Elisabetta De Bernardi, Chiara Gianoli, Rosalinda Ricotti, Marco Riboldi, Guido Baroni

Istituto Europeo di Oncologia

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The aim of this work is to propose an adaptation of a 4D Maximum Likelihood (ML) reconstruction strategy as a tool to improve the sensitivity of PET-based treatment verification in ion beam radiotherapy. PET images acquired during/shortly after the treatment (Measured PET) and an estimate of the same PET images derived from the treatment plan (Estimated PET) are considered as two frames of a 4D dataset. The algorithm iteratively estimates the annihilation events distribution in a reference frame and the deformation motion fields that map it in the Expected and Measured PET frames. Expected PET images can be then mapped into the Measured PET frame to verify the treatment. The details of the algorithm are presented and the strategy is preliminarily tested on an analytically simulated dataset. Convergence at different count statistics and ability to detect mismatches are assessed.

Original language	English
Title of host publication	2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479960972
DOIs	https://doi.org/10.1109/NSSMIC.2014.7431001
Publication status	Published - Mar 10 2016
Event	IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States Duration: Nov 8 2014 → Nov 15 2014

Other

Other	IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Country	United States
City	Seattle
Period	11/8/14 → 11/15/14

ASJC Scopus subject areas

Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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10.1109/NSSMIC.2014.7431001

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De Bernardi, E., Gianoli, C., Ricotti, R., Riboldi, M., & Baroni, G. (2016). Proposal of a 4D ML reconstruction strategy for PET-based treatment verification in ion beam radiotherapy. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7431001] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7431001

Proposal of a 4D ML reconstruction strategy for PET-based treatment verification in ion beam radiotherapy. / De Bernardi, Elisabetta; Gianoli, Chiara; Ricotti, Rosalinda; Riboldi, Marco; Baroni, Guido.

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7431001.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

De Bernardi, E, Gianoli, C, Ricotti, R, Riboldi, M & Baroni, G 2016, Proposal of a 4D ML reconstruction strategy for PET-based treatment verification in ion beam radiotherapy. in 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014., 7431001, Institute of Electrical and Electronics Engineers Inc., IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States, 11/8/14. https://doi.org/10.1109/NSSMIC.2014.7431001

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