TY - JOUR
T1 - Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials
T2 - Timing and specimen types
AU - Loi, Sherene
AU - Symmans, W. Fraser
AU - Bartlett, John M S
AU - Fumagalli, Debora
AU - Veer, Laura Van t
AU - Forbes, John F.
AU - Bedard, Philippe
AU - Denkert, Carsten
AU - Zujewski, JoAnne
AU - Viale, Giuseppe
AU - Pusztai, Lajos
AU - Esserman, Laura J.
AU - Leyland-Jones, Brian R.
PY - 2011/11
Y1 - 2011/11
N2 - In this Personal View, we outline proposals for uniform collection of biospecimens obtained in neoadjuvant breast cancer trials undertaken by the Breast International Group (BIG) and the National Cancer Institute-sponsored North American Breast Cancer Group (NABCG). These proposals aim to standardise collection of high-quality specimens, with respect to both type and timing, to enhance and allow integration of results obtained from neoadjuvant trials done by several groups. They should be considered in parallel with recommendations for tissue-specimen collection and handling previously developed by BIG and NABCG. We propose that tumour tissue (formalin-fixed, paraffin-embedded and samples dedicated for molecular studies) should be taken at baseline, 1-3 weeks after the start of treatment, and at definitive surgery, with clear prioritisation in the study protocol of number, order, and preservation of samples to be gathered. This step should be accompanied by blood collection (plasma, serum, and whole blood) whenever possible. We advocate strongly a move towards one diagnostic and research biopsy procedure in all women with breast cancers potentially suitable for neoadjuvant treatment. If possible, patients should be referred at the outset to specialised centres to give them the opportunity to participate in neoadjuvant clinical trials, thereby avoiding several biopsy procedures.
AB - In this Personal View, we outline proposals for uniform collection of biospecimens obtained in neoadjuvant breast cancer trials undertaken by the Breast International Group (BIG) and the National Cancer Institute-sponsored North American Breast Cancer Group (NABCG). These proposals aim to standardise collection of high-quality specimens, with respect to both type and timing, to enhance and allow integration of results obtained from neoadjuvant trials done by several groups. They should be considered in parallel with recommendations for tissue-specimen collection and handling previously developed by BIG and NABCG. We propose that tumour tissue (formalin-fixed, paraffin-embedded and samples dedicated for molecular studies) should be taken at baseline, 1-3 weeks after the start of treatment, and at definitive surgery, with clear prioritisation in the study protocol of number, order, and preservation of samples to be gathered. This step should be accompanied by blood collection (plasma, serum, and whole blood) whenever possible. We advocate strongly a move towards one diagnostic and research biopsy procedure in all women with breast cancers potentially suitable for neoadjuvant treatment. If possible, patients should be referred at the outset to specialised centres to give them the opportunity to participate in neoadjuvant clinical trials, thereby avoiding several biopsy procedures.
UR - http://www.scopus.com/inward/record.url?scp=81255168064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81255168064&partnerID=8YFLogxK
U2 - 10.1016/S1470-2045(11)70117-6
DO - 10.1016/S1470-2045(11)70117-6
M3 - Article
C2 - 21684810
AN - SCOPUS:81255168064
VL - 12
SP - 1162
EP - 1168
JO - The Lancet Oncology
JF - The Lancet Oncology
SN - 1470-2045
IS - 12
ER -