Propranolol and acetylsalicylic acid in migraine prophylaxis. Double-blind crossover study

A. Baldrati, P. Cortelli, G. Procaccianti, G. Gamberini, R. D'Alessandro, A. Baruzzi, T. Sacquegna

Research output: Contribution to journalArticle

Abstract

The aim of this double-blind crossover study was to compare the prophylactic effect of acetylsalicylic acid (ASA) with that of propranolol (PRP) in the treatment of migraine. Plasma concentrations of the two drugs were measured in order to investigate a possible relationship to the clinical effect. Compared to the pretreatment period, PRP and ASA reduced migraine index, frequency, duration, severity of attacks and headache days. Due to the limited number of patients, our results should be cautiously interpreted, however relevant the clinical improvement seemed. Improvement of migraine index was not related to different plasma levels of the two drugs.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalActa Neurologica Scandinavica
Volume67
Issue number3
Publication statusPublished - 1983

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Migraine Disorders
Double-Blind Method
Propranolol
Cross-Over Studies
Aspirin
Pharmaceutical Preparations
Headache
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Baldrati, A., Cortelli, P., Procaccianti, G., Gamberini, G., D'Alessandro, R., Baruzzi, A., & Sacquegna, T. (1983). Propranolol and acetylsalicylic acid in migraine prophylaxis. Double-blind crossover study. Acta Neurologica Scandinavica, 67(3), 181-186.

Propranolol and acetylsalicylic acid in migraine prophylaxis. Double-blind crossover study. / Baldrati, A.; Cortelli, P.; Procaccianti, G.; Gamberini, G.; D'Alessandro, R.; Baruzzi, A.; Sacquegna, T.

In: Acta Neurologica Scandinavica, Vol. 67, No. 3, 1983, p. 181-186.

Research output: Contribution to journalArticle

Baldrati, A, Cortelli, P, Procaccianti, G, Gamberini, G, D'Alessandro, R, Baruzzi, A & Sacquegna, T 1983, 'Propranolol and acetylsalicylic acid in migraine prophylaxis. Double-blind crossover study', Acta Neurologica Scandinavica, vol. 67, no. 3, pp. 181-186.
Baldrati, A. ; Cortelli, P. ; Procaccianti, G. ; Gamberini, G. ; D'Alessandro, R. ; Baruzzi, A. ; Sacquegna, T. / Propranolol and acetylsalicylic acid in migraine prophylaxis. Double-blind crossover study. In: Acta Neurologica Scandinavica. 1983 ; Vol. 67, No. 3. pp. 181-186.
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