Propranolol plasma binding and serum lipids during chronic therapy in migraine patients

F. Albani, R. Riva, P. Cortelli, M. Contin, A. Baruzzi

Research output: Contribution to journalArticle

Abstract

Plasma protein binding of propranolol (PROP) was determined in 18 migraine patients chronically treated with different doses (from 60 to 240 mg/day) of the drug. In 9 patients serum lipids and PROP binding were determined before and during the therapy. Free fractions of PROP ranged from 4.7 to 13.3% and they were similar to those found in vitro in healthy volunteers. Total and free concentrations were highly correlated (r = 0.929; p <0.001); correlations between daily doses (in mg/kg) and free and total concentrations were very similar: r = 0.76 and r = 0.73 respectively. Changes in binding and serum lipids during the therapy were insignificant and unrelated.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume23
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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