Plasma protein binding of propranolol (PROP) was determined in 18 migraine patients chronically treated with different doses (from 60 to 240 mg/day) of the drug. In 9 patients serum lipids and PROP binding were determined before and during the therapy. Free fractions of PROP ranged from 4.7 to 13.3% and they were similar to those found in vitro in healthy volunteers. Total and free concentrations were highly correlated (r = 0.929; p <0.001); correlations between daily doses (in mg/kg) and free and total concentrations were very similar: r = 0.76 and r = 0.73 respectively. Changes in binding and serum lipids during the therapy were insignificant and unrelated.
|Number of pages||3|
|Journal||International Journal of Clinical Pharmacology Therapy and Toxicology|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Pharmacology (medical)