Propranolol Plasma Levels and Relief of Migraine: Relationship Between Plasma Propranolol and 4-Hydroxypropranolol Concentrations and Clinical Effects

Pietro Cortelli, Tommaso Sacquegna, Fiorenzo Albani, Anna Baldrati, Roberto D'Alessandro, Agostino Baruzzi, Elio Lugaresi

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17 patients during treatment with oral racemic propranolol hydrochloride in doses of 40 to 240 mg/day. Propranolol decreased the migraine index more than 70% in 13 patients: five patients at a dosage of 40 mg/day, five patients at a dosage of 120 mg/day, and three patients at a dosage of 240 mg/ day. Three patients did not achieve a good improvement of migraine at any of the doses used. The relief of migraine was not directly related to the propranolol and 4-hydroxypropranolol plasma concentrations.

Original languageEnglish
Pages (from-to)46-48
Number of pages3
JournalArchives of Neurology
Volume42
Issue number1
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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