Propriospinal myoclonus at sleep onset

P. Montagna, F. Provini, R. Vetrugno

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To describe the clinical and polygraphic features of propriospinal myoclonus (PSM) at sleep onset. Material and methods: PSM was first described in 1997 in patients with jerks occurring in the relaxation period preceding sleep. EMG showed jerks to arise in spinally innervated muscles, propagating thereafter to rostral and caudal muscles at a low speed, typical of propriospinal pathways. Results: PSM arose when EEG alpha activity spread over the scalp and disappeared during either active wakefulness or actual sleep. In some patients EMG activity could sometimes remain localized to the abdominal muscles, propagating to other segments only in fully developed jerks. Neurological examination, brain and spinal MRI were usually normal and clonazepam afforded partial improvement. PSM has been recently observed also in restless legs syndrome, during relaxed wakefulness preceding falling asleep, coexisting with motor restlessness and sensory discomfort. PSM disappeared when spindles and K-complexes and typical Periodic Limb Movements appeared with EMG activity limited to leg muscles, without propriospinal propagation. Conclusions: Conceivably, PSM arises in axial muscles due to some spinal generator set into motion by facilitating influences characteristic of the wake-sleep transition and then undergoes multimeric propriospinal propagation. In the International Classification of Sleep Disorders (ICSD-2), PSM is listed in chapter VII, among the "Isolated symptoms, apparently normal variants and unresolved issues".

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Volume36
Issue number5-6
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Insomnia
  • Myoclonus
  • Propriospinal
  • Sleep
  • Sleep-wake transition
  • Spinal

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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