Prosopagnosia as unusual presentation of semantic dementia: a case study

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Object: Semantic dementia is one of the main clinical variants of frontotemporal dementia and it is characterized by severe loss of conceptual knowledge with relative preservation of other cortical abilities. Methods: We described a case of a patient affected by right temporal variant of frontotemporal lobar degeneration, characterized by prosopagnosia as an unusual disease onset. Results: The neuropsychological evaluation showed a progressive deficit in face recognition and a slow decline in language in the absence of behavioral alterations. Magnetic resonance imaging showed diffuse vascular ischemic lesions, cortical atrophy in bilateral temporal lobes, and a marked bilateral decrease hippocampal volume, mainly involving the right side. Conclusions: Our findings suggest that prosopagnosia could be a predictive marker of atypical semantic dementia onset.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalActa Clinica Belgica
Publication statusAccepted/In press - Aug 4 2016


  • Frontotemporal lobar degeneration
  • Hippocampus atrophy
  • Prosopagnosia
  • Semantic dementia

ASJC Scopus subject areas

  • Medicine(all)


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