Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study

Fabio Lauria, Alfonso Siani, Karin Bammann, Ronja Foraita, Inge Huybrechts, Licia Iacoviello, Anna C. Koni, Yannis Kourides, Staffan Marild, Denes Molnar, Luis A. Moreno, Iris Pigeot, Yannis P. Pitsiladis, Toomas Veidebaum, Paola Russo

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Abstract

Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all pA = 1.95, 95% CI = (1.29; 2.97)]. Conclusions: We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.

Original languageEnglish
Article numbere48876
JournalPLoS One
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 14 2012

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lauria, F., Siani, A., Bammann, K., Foraita, R., Huybrechts, I., Iacoviello, L., Koni, A. C., Kourides, Y., Marild, S., Molnar, D., Moreno, L. A., Pigeot, I., Pitsiladis, Y. P., Veidebaum, T., & Russo, P. (2012). Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study. PLoS One, 7(11), [e48876]. https://doi.org/10.1371/journal.pone.0048876