Abstract
Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all pA = 1.95, 95% CI = (1.29; 2.97)]. Conclusions: We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.
| Original language | English |
|---|---|
| Article number | e48876 |
| Journal | PLoS One |
| Volume | 7 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 14 2012 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children : Results of the IDEFICS Study. / Lauria, Fabio; Siani, Alfonso; Bammann, Karin; Foraita, Ronja; Huybrechts, Inge; Iacoviello, Licia; Koni, Anna C.; Kourides, Yannis; Marild, Staffan; Molnar, Denes; Moreno, Luis A.; Pigeot, Iris; Pitsiladis, Yannis P.; Veidebaum, Toomas; Russo, Paola.
In: PLoS One, Vol. 7, No. 11, e48876, 14.11.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children
T2 - Results of the IDEFICS Study
AU - Lauria, Fabio
AU - Siani, Alfonso
AU - Bammann, Karin
AU - Foraita, Ronja
AU - Huybrechts, Inge
AU - Iacoviello, Licia
AU - Koni, Anna C.
AU - Kourides, Yannis
AU - Marild, Staffan
AU - Molnar, Denes
AU - Moreno, Luis A.
AU - Pigeot, Iris
AU - Pitsiladis, Yannis P.
AU - Veidebaum, Toomas
AU - Russo, Paola
PY - 2012/11/14
Y1 - 2012/11/14
N2 - Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all pA = 1.95, 95% CI = (1.29; 2.97)]. Conclusions: We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.
AB - Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all pA = 1.95, 95% CI = (1.29; 2.97)]. Conclusions: We confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.
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U2 - 10.1371/journal.pone.0048876
DO - 10.1371/journal.pone.0048876
M3 - Article
VL - 7
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e48876
ER -