Prospective data registration and clinical trials for particle therapy in Europe

Johannes A. Langendijk, Roberto Orecchia, Karin Haustermans, Daniel Zips, Jacques Balosso, Denis Lacombe, Yolande Lievens, Damien C. Weber, Cai Grau, Esther G.C. Troost

Research output: Contribution to journalReview article

Abstract

The overarching aim of work package 1 of the European Proton Therapy Network (EPTN) is to create a firm basis for evidence-based particle therapy at the European level. To achieve this, this work package will set up a worldwide unique prospective data registration programme for nine different tumour sites. Such programme will provide more insights into the current practice across all European particle therapy centres and into the results of particle therapy with regard to radiation-induced toxicity and efficacy in terms of local control and survival. More importantly, prospective data registration provides major opportunities to continuously improve the quality of particle therapy, by defining bench marks, to identify best practices that may learn others to improve quality of particle therapy, to synchronize selection criteria and to create more homogeneous patient cohorts to evaluate results, which is particularly important in rare tumours. This will be supported by EORTC through existing and new IT-infrastructure for data collection in different formats next to QA-platforms. In addition, work package 1 will define the requirements for high quality clinical trials in order to enhance high quality clinical trial proposals and determine alternative methods for RCT, such as the model-based approach.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalRadiotherapy and Oncology
Volume128
Issue number1
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Model-based approach
  • Particle therapy
  • Prospective data registry
  • Proton therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Prospective data registration and clinical trials for particle therapy in Europe'. Together they form a unique fingerprint.

  • Cite this

    Langendijk, J. A., Orecchia, R., Haustermans, K., Zips, D., Balosso, J., Lacombe, D., Lievens, Y., Weber, D. C., Grau, C., & Troost, E. G. C. (2018). Prospective data registration and clinical trials for particle therapy in Europe. Radiotherapy and Oncology, 128(1), 9-13. https://doi.org/10.1016/j.radonc.2018.06.001