Prospective evaluation of metabolic syndrome and its features in a single-center series of hematopoietic stem cell transplantation recipients

Claudio Annaloro, Lorena Airaghi, Diana Giannarelli, Gabriella Mometto, Alessandra Orsatti, Giorgia Saporiti, Federica Irene Grifoni, Marina Baldini, Elena Tagliaferri, Daniele Vincenti, Diletta Maira, Francesco Onida, Agostino Cortelezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Available studies on metabolic syndrome (MS) after hematopoietic stem cell transplantation (HSCT) are retrospective with heterogeneous inclusion criteria, and little is known about the early post-transplant phase. In our prospective study, clinical and laboratory data were collected in 100 HSCT recipients, 48 allogeneic and 52 autologous, at baseline, at + 30, + 100 and + 360 days. At baseline, MS was observed in 24 patients, significantly associated with insulin resistance and leptin on multivariate analysis. At + 30, the diagnosis of MS was confirmed in 43 patients, significantly related to insulin resistance and allogeneic transplants. If the whole series was considered, patients with MS had significantly higher mortality from any cause. The baseline presence of any MS feature was a predictor of + 30 MS. Isolated occurrences of MS features were related to hyperleptinemia and hyperinsulinemia, except in the case of low HDL cholesterol, linked to adiponectin and resistin. Our data confirm that patients undergoing HSCT have a high prevalence of MS, with hyperleptinemia playing a major role. The early peak of new MS cases is primarily attributable to insulin resistance, notably but not exclusively immunosuppression-induced; the subsequent long-term increase in MS cases may be an effect of persistent adipokine imbalance.

Original languageEnglish
Pages (from-to)2471-2478
JournalAnnals of Hematology
Volume97
Issue number12
DOIs
Publication statusPublished - 2018

Keywords

  • Adipokines
  • Hematopoietic stem cell transplantation
  • Insulin resistance
  • Leptin
  • Metabolic syndrome

ASJC Scopus subject areas

  • Hematology

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