Prospective evaluation of the diagnostic efficacy of a mathematical model in acute pancreatitis

G. Masoero, A. Andriulli, L. Capussotti

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In the present study a prospective evaluation is made of the discriminant power of the multivariate analysis of serum and urine amylase activity and of the C(am)/C(cr) ratio, comparing the sensitivity, specificity, predictive value of a positive and a negative result of both the discrimant functin and the C(am)C(cr) ratio in 60 patients with various gastrointestinal diseases. Mean values of both the C(am)/C(cr) ratio and the discriminant funcion were significantly higher in patients with AP. This finding, which could suggest a good diagnostic reliability for each test, is challenged by the presence of overlapping data between the two groups. However, the diagnostic efficacy of the discriminant function appears superior to the C(am)C(cr) ratio in all the parameters considered in this study. In patients with a discriminant function value below 24 (negative threshold) there will be a 92% degree of probability to rule out of the presence of AP. In conclusion, since this function is based on the simple estimation of serum and urine amylase activity, its use is recommended in the diagnosis of AP.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalItalian Journal of Gastroenterology
Issue number2
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Gastroenterology


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