Prospective memory performance in individuals with parkinson's disease who have mild cognitive impairment

Alberto Costa, Antonella Peppe, Silvia Zabberoni, Francesca Serafini, Francesco Barban, Francesco Scalici, Carlo Caltagirone, Giovanni Augusto Carlesimo

Research output: Contribution to journalArticle

Abstract

Objective: Prospective memory (PM) is the ability to keep in memory and realize future intentions. We aimed at investigating whether in Parkinson's disease (PD) PM deficits are related to mild cognitive impairment (MCI). Other aims were to investigate the cognitive abilities underlying PM performance, and the association between PM performance and measures of daily living functioning. Method: The study included 15 PD patients with single domain MCI, 15 with multiple domain MCI, 17 PD patients without cognitive disorders (PDNC) and 25 healthy controls (HCs). All subjects were administered a PM procedure that included focal (PM cue is processed in the ongoing task) and nonfocal (PM cue is not processed in the ongoing task) conditions. PD patients were administered an extensive neuropsychological battery and scales to assess daily living abilities. Results: PD patients with MCI (both single and multiple domains) showed lower accuracy on all PM conditions than both HC and PDNC patients. This was predicted by their scores on shifting indices. Conversely, PM accuracy of PDNC patients was comparable to HCs. Regression analyses revealed that PD patients' PM performance significantly predicted scores on daily living scales Conclusions: Results suggest that PM efficiency is not tout-court reduced in PD patients, but it specifically depends on the presence of MCI. Moreover, decreased executive functioning, but not episodic memory failure, accounts for a significant proportion of variance in PM performance. Finally, PM accuracy indices were found to be associated with measures of global daily living functioning and management of medication.

Original languageEnglish
Pages (from-to)782-791
Number of pages10
JournalNeuropsychology
Volume29
Issue number5
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Cognitive deficits
  • Executive functions
  • Memory for intentions
  • Movement disorders
  • Neurodegenerative syndromes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

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