Studio multicentrico osservazionale prospettico su epilessia non idiopatica focale

Translated title of the contribution: Prospective multicentre study of non-idiopathic partial epilepsy

D. De Carlo, M. Vecchi, E. Perissinotto, C. Barba, R. Guerrini, D. Battaglia, G. Cantalupo, S. Casellato, E. Cesaroni, L. Fusco, I. Giordano, G. Granata, M. Mastrangelo, A. Verrotti, C. Boniver, N. Stivala, E. Albamonte, D. Ranalli, B. Piccolo, G. NiedduS. Cappanera, N. Zamponi, N. Specchio, F. Vigevano, F. Palestro, E. Freri, I. De Giorgi, F. Ragona, I. Fiocchi, S. Matricardi, S. Francione

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to identify the early predictors of clinical and neuropsychological outcomes in non-idiopathic partial epilepsy in childhood. One hundred fifty-four consecutive patients (88 M, 66 F; mean age: 5 yrs and 3 m, range 1 m-12yrs) were prospectively enrolled at 14 Italian Centers specialized in childhood epilepsy. Results: there was a positive family history of epilepsy and/or febrile seizures in 24.2%; status epilepticus at onset in 11%. At baseline seizure semiology was 34% frontal; 37% temporal; 29% posterior. EEG at enrollment: focal 50.7%; multilobar 20.8%; multifocal 22.7%; diffuse 0.6%; normal 5.2%. At the first presentation MRI was negative in 59/150 patients (39.1%); in 60.9% (93/150) MRI revealed abnormalities: neoplasm 8.7%, focal cortical dysplasias 29.3%; vascular disease 21.7%; scar results 8.7%, nonspecific abnormalities (hydrocephalus, periventricular leukomalacia, hypoxic-ischemic outcomes) in 31.5%. Most patients (65.6%, 101/154) were in monotherapy; the drug most commonly used was CBZ; in 15.0% (23/154) polytherapy was required for seizures control; conversely 30 patients did not need treatment at baseline: 30.5% had an abnormal neurological examination; 43.7% (55/132) had cognitive function impaired and 19.8% (17/86) presented an altered psychopathological profile. At the 6-month follow-up, seizures recurred in 39.8% of patients and the predictors of recurrence were abnormalities on cerebral MRI, neurological examination and cognitive profile. More data, at longer follow-up, are needed to delineate the predictors of intractability in childhood.

Translated title of the contributionProspective multicentre study of non-idiopathic partial epilepsy
Original languageItalian
Pages (from-to)24-27
Number of pages4
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number145
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Clinical Neurology

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