TY - JOUR
T1 - Studio multicentrico osservazionale prospettico su epilessia non idiopatica focale
AU - De Carlo, D.
AU - Vecchi, M.
AU - Perissinotto, E.
AU - Barba, C.
AU - Guerrini, R.
AU - Battaglia, D.
AU - Cantalupo, G.
AU - Casellato, S.
AU - Cesaroni, E.
AU - Fusco, L.
AU - Giordano, I.
AU - Granata, G.
AU - Mastrangelo, M.
AU - Verrotti, A.
AU - Boniver, C.
AU - Stivala, N.
AU - Albamonte, E.
AU - Ranalli, D.
AU - Piccolo, B.
AU - Nieddu, G.
AU - Cappanera, S.
AU - Zamponi, N.
AU - Specchio, N.
AU - Vigevano, F.
AU - Palestro, F.
AU - Freri, E.
AU - De Giorgi, I.
AU - Ragona, F.
AU - Fiocchi, I.
AU - Matricardi, S.
AU - Francione, S.
PY - 2013/4
Y1 - 2013/4
N2 - The aim of the study was to identify the early predictors of clinical and neuropsychological outcomes in non-idiopathic partial epilepsy in childhood. One hundred fifty-four consecutive patients (88 M, 66 F; mean age: 5 yrs and 3 m, range 1 m-12yrs) were prospectively enrolled at 14 Italian Centers specialized in childhood epilepsy. Results: there was a positive family history of epilepsy and/or febrile seizures in 24.2%; status epilepticus at onset in 11%. At baseline seizure semiology was 34% frontal; 37% temporal; 29% posterior. EEG at enrollment: focal 50.7%; multilobar 20.8%; multifocal 22.7%; diffuse 0.6%; normal 5.2%. At the first presentation MRI was negative in 59/150 patients (39.1%); in 60.9% (93/150) MRI revealed abnormalities: neoplasm 8.7%, focal cortical dysplasias 29.3%; vascular disease 21.7%; scar results 8.7%, nonspecific abnormalities (hydrocephalus, periventricular leukomalacia, hypoxic-ischemic outcomes) in 31.5%. Most patients (65.6%, 101/154) were in monotherapy; the drug most commonly used was CBZ; in 15.0% (23/154) polytherapy was required for seizures control; conversely 30 patients did not need treatment at baseline: 30.5% had an abnormal neurological examination; 43.7% (55/132) had cognitive function impaired and 19.8% (17/86) presented an altered psychopathological profile. At the 6-month follow-up, seizures recurred in 39.8% of patients and the predictors of recurrence were abnormalities on cerebral MRI, neurological examination and cognitive profile. More data, at longer follow-up, are needed to delineate the predictors of intractability in childhood.
AB - The aim of the study was to identify the early predictors of clinical and neuropsychological outcomes in non-idiopathic partial epilepsy in childhood. One hundred fifty-four consecutive patients (88 M, 66 F; mean age: 5 yrs and 3 m, range 1 m-12yrs) were prospectively enrolled at 14 Italian Centers specialized in childhood epilepsy. Results: there was a positive family history of epilepsy and/or febrile seizures in 24.2%; status epilepticus at onset in 11%. At baseline seizure semiology was 34% frontal; 37% temporal; 29% posterior. EEG at enrollment: focal 50.7%; multilobar 20.8%; multifocal 22.7%; diffuse 0.6%; normal 5.2%. At the first presentation MRI was negative in 59/150 patients (39.1%); in 60.9% (93/150) MRI revealed abnormalities: neoplasm 8.7%, focal cortical dysplasias 29.3%; vascular disease 21.7%; scar results 8.7%, nonspecific abnormalities (hydrocephalus, periventricular leukomalacia, hypoxic-ischemic outcomes) in 31.5%. Most patients (65.6%, 101/154) were in monotherapy; the drug most commonly used was CBZ; in 15.0% (23/154) polytherapy was required for seizures control; conversely 30 patients did not need treatment at baseline: 30.5% had an abnormal neurological examination; 43.7% (55/132) had cognitive function impaired and 19.8% (17/86) presented an altered psychopathological profile. At the 6-month follow-up, seizures recurred in 39.8% of patients and the predictors of recurrence were abnormalities on cerebral MRI, neurological examination and cognitive profile. More data, at longer follow-up, are needed to delineate the predictors of intractability in childhood.
KW - Childhood
KW - Intractable epilepsy
KW - Partial seizure
KW - Predictors
KW - Symptomatic seizure
UR - http://www.scopus.com/inward/record.url?scp=84887279718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887279718&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:84887279718
SP - 24
EP - 27
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 145
ER -