Abstract
A multicentre, prospective trial was organised to clarify the role of protein restriction in the progression of chronic renal insufficiency (CRI). 456 adult patients were assigned either a low-protein diet (0·6 g/kg body weight daily; n=226) or a "normal" controlled-protein diet (1·0 g/kg daily; n=230) and were stratified into three groups (A-C) with increasing baseline plasma creatinine concentrations. Each patient was followed up for 2 years or until an endpoint (a doubling of the baseline plasma creatinine or a need for dialysis) was reached. The difference between the diet groups in cumulative renal survival defined by these endpoints (27 low-protein, 42 controlled-protein) was of borderline significance (p
Original language | English |
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Pages (from-to) | 1299-1304 |
Number of pages | 6 |
Journal | Lancet |
Volume | 337 |
Issue number | 8753 |
DOIs | |
Publication status | Published - Jun 1 1991 |
ASJC Scopus subject areas
- Medicine(all)