Prospective, randomised, multicentre trial of effect of protein restriction on progression of chronic renal insufficiency

F. Locatelli, D. Alberti, G. Graziani, G. Buccianti, B. Redaelli, A. Giangrande

Research output: Contribution to journalArticle

Abstract

A multicentre, prospective trial was organised to clarify the role of protein restriction in the progression of chronic renal insufficiency (CRI). 456 adult patients were assigned either a low-protein diet (0·6 g/kg body weight daily; n=226) or a "normal" controlled-protein diet (1·0 g/kg daily; n=230) and were stratified into three groups (A-C) with increasing baseline plasma creatinine concentrations. Each patient was followed up for 2 years or until an endpoint (a doubling of the baseline plasma creatinine or a need for dialysis) was reached. The difference between the diet groups in cumulative renal survival defined by these endpoints (27 low-protein, 42 controlled-protein) was of borderline significance (p

Original languageEnglish
Pages (from-to)1299-1304
Number of pages6
JournalLancet
Volume337
Issue number8753
DOIs
Publication statusPublished - Jun 1 1991

ASJC Scopus subject areas

  • Medicine(all)

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    Locatelli, F., Alberti, D., Graziani, G., Buccianti, G., Redaelli, B., & Giangrande, A. (1991). Prospective, randomised, multicentre trial of effect of protein restriction on progression of chronic renal insufficiency. Lancet, 337(8753), 1299-1304. https://doi.org/10.1016/0140-6736(91)92977-A