Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation

The PAF study

M. Brignole, L. Gianfranchi, C. Menozzi, P. Alboni, G. Musso, M. G. Bongiorni, M. Gasparini, A. Raviele, G. Lolli, N. Paparella, S. Acquarone

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalEuropace
Volume1
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Atrial Fibrillation
Prospective Studies
Drug Therapy
Anti-Arrhythmia Agents
Quality of Life
Pharmacology
Recurrence
Therapeutics

Keywords

  • Atrial fibrillation
  • Catheter ablation pacemaker
  • Mode-switching

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation : The PAF study. / Brignole, M.; Gianfranchi, L.; Menozzi, C.; Alboni, P.; Musso, G.; Bongiorni, M. G.; Gasparini, M.; Raviele, A.; Lolli, G.; Paparella, N.; Acquarone, S.

In: Europace, Vol. 1, No. 1, 1999, p. 15-19.

Research output: Contribution to journalArticle

Brignole, M. ; Gianfranchi, L. ; Menozzi, C. ; Alboni, P. ; Musso, G. ; Bongiorni, M. G. ; Gasparini, M. ; Raviele, A. ; Lolli, G. ; Paparella, N. ; Acquarone, S. / Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation : The PAF study. In: Europace. 1999 ; Vol. 1, No. 1. pp. 15-19.
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