Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy

Faisal M. Merchant, Jorge A. Salerno-Uriarte, Fabrizio Caravati, Stefania Falcone, Giulio Molon, Daniele Marangoni, Grzegorz Raczak, Ludmila Danilowicz-Szymanowicz, Roberto F E Pedretti, Simona Sarzi Braga, Takanori Ikeda, Leonardo Calo, Annamaria Martino, Demet Erciyes, Maurizio Piancastelli, Philippe Maury, Richard J. Cohen, Antonis A. Armoundas

Research output: Contribution to journalArticle

Abstract

Background: We hypothesized that a negative microvolt T-wave alternans (MTWA) test would identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillator (ICD) therapy in a prospective cohort. Methods and Results: Data were pooled from 8 centers where MTWA testing was performed specifically for the purpose of guiding primary prevention ICD implantation. Cohorts were included if the ratio of ICDs implanted in patients who were MTWA "non-negative" to patients who were MTWA negative was >2:1, indicating that MTWA testing had a significant impact on the decision to implant an ICD. The pooled cohort included 651 patients: 371 MTWA non-negative and 280 MTWA negative. Among non-negative patients, 62% underwent ICD implantation whereas only 13% of MTWA-negative patients received an ICD (P

Original languageEnglish
Pages (from-to)1912-1919
Number of pages8
JournalCirculation Journal
Volume79
Issue number9
DOIs
Publication statusPublished - Aug 25 2015

Keywords

  • Implantable cardioverter defibrillator
  • Microvolt T wave alternans
  • Primary prevention
  • Risk stratification
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy'. Together they form a unique fingerprint.

  • Cite this

    Merchant, F. M., Salerno-Uriarte, J. A., Caravati, F., Falcone, S., Molon, G., Marangoni, D., Raczak, G., Danilowicz-Szymanowicz, L., Pedretti, R. F. E., Braga, S. S., Ikeda, T., Calo, L., Martino, A., Erciyes, D., Piancastelli, M., Maury, P., Cohen, R. J., & Armoundas, A. A. (2015). Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy. Circulation Journal, 79(9), 1912-1919. https://doi.org/10.1253/circj.CJ-15-0253