Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy

Faisal M. Merchant, Jorge A. Salerno-Uriarte, Fabrizio Caravati, Stefania Falcone, Giulio Molon, Daniele Marangoni, Grzegorz Raczak, Ludmila Danilowicz-Szymanowicz, Roberto F E Pedretti, Simona Sarzi Braga, Takanori Ikeda, Leonardo Calo, Annamaria Martino, Demet Erciyes, Maurizio Piancastelli, Philippe Maury, Richard J. Cohen, Antonis A. Armoundas

Research output: Contribution to journalArticle

Abstract

Background: We hypothesized that a negative microvolt T-wave alternans (MTWA) test would identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillator (ICD) therapy in a prospective cohort. Methods and Results: Data were pooled from 8 centers where MTWA testing was performed specifically for the purpose of guiding primary prevention ICD implantation. Cohorts were included if the ratio of ICDs implanted in patients who were MTWA "non-negative" to patients who were MTWA negative was >2:1, indicating that MTWA testing had a significant impact on the decision to implant an ICD. The pooled cohort included 651 patients: 371 MTWA non-negative and 280 MTWA negative. Among non-negative patients, 62% underwent ICD implantation whereas only 13% of MTWA-negative patients received an ICD (P

Original languageEnglish
Pages (from-to)1912-1919
Number of pages8
JournalCirculation Journal
Volume79
Issue number9
DOIs
Publication statusPublished - Aug 25 2015

Fingerprint

Implantable Defibrillators
Primary Prevention
Therapeutics

Keywords

  • Implantable cardioverter defibrillator
  • Microvolt T wave alternans
  • Primary prevention
  • Risk stratification
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Merchant, F. M., Salerno-Uriarte, J. A., Caravati, F., Falcone, S., Molon, G., Marangoni, D., ... Armoundas, A. A. (2015). Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy. Circulation Journal, 79(9), 1912-1919. https://doi.org/10.1253/circj.CJ-15-0253

Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy. / Merchant, Faisal M.; Salerno-Uriarte, Jorge A.; Caravati, Fabrizio; Falcone, Stefania; Molon, Giulio; Marangoni, Daniele; Raczak, Grzegorz; Danilowicz-Szymanowicz, Ludmila; Pedretti, Roberto F E; Braga, Simona Sarzi; Ikeda, Takanori; Calo, Leonardo; Martino, Annamaria; Erciyes, Demet; Piancastelli, Maurizio; Maury, Philippe; Cohen, Richard J.; Armoundas, Antonis A.

In: Circulation Journal, Vol. 79, No. 9, 25.08.2015, p. 1912-1919.

Research output: Contribution to journalArticle

Merchant, FM, Salerno-Uriarte, JA, Caravati, F, Falcone, S, Molon, G, Marangoni, D, Raczak, G, Danilowicz-Szymanowicz, L, Pedretti, RFE, Braga, SS, Ikeda, T, Calo, L, Martino, A, Erciyes, D, Piancastelli, M, Maury, P, Cohen, RJ & Armoundas, AA 2015, 'Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy', Circulation Journal, vol. 79, no. 9, pp. 1912-1919. https://doi.org/10.1253/circj.CJ-15-0253
Merchant, Faisal M. ; Salerno-Uriarte, Jorge A. ; Caravati, Fabrizio ; Falcone, Stefania ; Molon, Giulio ; Marangoni, Daniele ; Raczak, Grzegorz ; Danilowicz-Szymanowicz, Ludmila ; Pedretti, Roberto F E ; Braga, Simona Sarzi ; Ikeda, Takanori ; Calo, Leonardo ; Martino, Annamaria ; Erciyes, Demet ; Piancastelli, Maurizio ; Maury, Philippe ; Cohen, Richard J. ; Armoundas, Antonis A. / Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy. In: Circulation Journal. 2015 ; Vol. 79, No. 9. pp. 1912-1919.
@article{229b90b05b734ec1a07b040a2241918a,
title = "Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy",
abstract = "Background: We hypothesized that a negative microvolt T-wave alternans (MTWA) test would identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillator (ICD) therapy in a prospective cohort. Methods and Results: Data were pooled from 8 centers where MTWA testing was performed specifically for the purpose of guiding primary prevention ICD implantation. Cohorts were included if the ratio of ICDs implanted in patients who were MTWA {"}non-negative{"} to patients who were MTWA negative was >2:1, indicating that MTWA testing had a significant impact on the decision to implant an ICD. The pooled cohort included 651 patients: 371 MTWA non-negative and 280 MTWA negative. Among non-negative patients, 62{\%} underwent ICD implantation whereas only 13{\%} of MTWA-negative patients received an ICD (P",
keywords = "Implantable cardioverter defibrillator, Microvolt T wave alternans, Primary prevention, Risk stratification, Sudden cardiac death",
author = "Merchant, {Faisal M.} and Salerno-Uriarte, {Jorge A.} and Fabrizio Caravati and Stefania Falcone and Giulio Molon and Daniele Marangoni and Grzegorz Raczak and Ludmila Danilowicz-Szymanowicz and Pedretti, {Roberto F E} and Braga, {Simona Sarzi} and Takanori Ikeda and Leonardo Calo and Annamaria Martino and Demet Erciyes and Maurizio Piancastelli and Philippe Maury and Cohen, {Richard J.} and Armoundas, {Antonis A.}",
year = "2015",
month = "8",
day = "25",
doi = "10.1253/circj.CJ-15-0253",
language = "English",
volume = "79",
pages = "1912--1919",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "9",

}

TY - JOUR

T1 - Prospective use of microvolt T-wave alternans testing to guide primary prevention implantable cardioverter defibrillator therapy

AU - Merchant, Faisal M.

AU - Salerno-Uriarte, Jorge A.

AU - Caravati, Fabrizio

AU - Falcone, Stefania

AU - Molon, Giulio

AU - Marangoni, Daniele

AU - Raczak, Grzegorz

AU - Danilowicz-Szymanowicz, Ludmila

AU - Pedretti, Roberto F E

AU - Braga, Simona Sarzi

AU - Ikeda, Takanori

AU - Calo, Leonardo

AU - Martino, Annamaria

AU - Erciyes, Demet

AU - Piancastelli, Maurizio

AU - Maury, Philippe

AU - Cohen, Richard J.

AU - Armoundas, Antonis A.

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Background: We hypothesized that a negative microvolt T-wave alternans (MTWA) test would identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillator (ICD) therapy in a prospective cohort. Methods and Results: Data were pooled from 8 centers where MTWA testing was performed specifically for the purpose of guiding primary prevention ICD implantation. Cohorts were included if the ratio of ICDs implanted in patients who were MTWA "non-negative" to patients who were MTWA negative was >2:1, indicating that MTWA testing had a significant impact on the decision to implant an ICD. The pooled cohort included 651 patients: 371 MTWA non-negative and 280 MTWA negative. Among non-negative patients, 62% underwent ICD implantation whereas only 13% of MTWA-negative patients received an ICD (P

AB - Background: We hypothesized that a negative microvolt T-wave alternans (MTWA) test would identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillator (ICD) therapy in a prospective cohort. Methods and Results: Data were pooled from 8 centers where MTWA testing was performed specifically for the purpose of guiding primary prevention ICD implantation. Cohorts were included if the ratio of ICDs implanted in patients who were MTWA "non-negative" to patients who were MTWA negative was >2:1, indicating that MTWA testing had a significant impact on the decision to implant an ICD. The pooled cohort included 651 patients: 371 MTWA non-negative and 280 MTWA negative. Among non-negative patients, 62% underwent ICD implantation whereas only 13% of MTWA-negative patients received an ICD (P

KW - Implantable cardioverter defibrillator

KW - Microvolt T wave alternans

KW - Primary prevention

KW - Risk stratification

KW - Sudden cardiac death

UR - http://www.scopus.com/inward/record.url?scp=84940025309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940025309&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-15-0253

DO - 10.1253/circj.CJ-15-0253

M3 - Article

C2 - 26073692

AN - SCOPUS:84940025309

VL - 79

SP - 1912

EP - 1919

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 9

ER -