Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

Massimo Gentile, Giovanna Cutrona, Stefano Molica, Fiorella Ilariucci, F. R. Mauro, Nicola Di Renzo, Francesco Di Raimondo, Iolanda Vincelli, Katia Todoerti, Serena Matis, Caterina Musolino, Sonia Fabris, Marta Lionetti, Luciano Levato, Simonetta Zupo, F. Angrilli, Ugo Consoli, Gianluca Festini, Giuseppe Longo, Agostino CortelezziPellegrino Musto, Massimo Federico, Antonino Neri, Manlio Ferrarini, Fortunato Morabito

Research output: Contribution to journalArticle

Abstract

Objective: We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients. Methods: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549). Results: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalEuropean Journal of Haematology
Volume96
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Keywords

  • Abdominal CT scan
  • Chronic lymphocytic leukemia
  • Clinical monoclonal B-cell lymphocytosis
  • Early stage
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Gentile, M., Cutrona, G., Molica, S., Ilariucci, F., Mauro, F. R., Di Renzo, N., Di Raimondo, F., Vincelli, I., Todoerti, K., Matis, S., Musolino, C., Fabris, S., Lionetti, M., Levato, L., Zupo, S., Angrilli, F., Consoli, U., Festini, G., Longo, G., ... Morabito, F. (2016). Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study. European Journal of Haematology, 96(1), 36-45. https://doi.org/10.1111/ejh.12545