Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

Massimo Gentile; Giovanna Cutrona; Stefano Molica; Fiorella Ilariucci; F. R. Mauro; Nicola Di Renzo; Francesco Di Raimondo; Iolanda Vincelli; Katia Todoerti; Serena Matis; Caterina Musolino; Sonia Fabris; Marta Lionetti; Luciano Levato; Simonetta Zupo; F. Angrilli; Ugo Consoli; Gianluca Festini; Giuseppe Longo; Agostino Cortelezzi; Pellegrino Musto; Massimo Federico; Antonino Neri; Manlio Ferrarini; Fortunato Morabito

doi:10.1111/ejh.12545

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

Massimo Gentile, Giovanna Cutrona, Stefano Molica, Fiorella Ilariucci, F. R. Mauro, Nicola Di Renzo, Francesco Di Raimondo, Iolanda Vincelli, Katia Todoerti, Serena Matis, Caterina Musolino, Sonia Fabris, Marta Lionetti, Luciano Levato, Simonetta Zupo, F. Angrilli, Ugo Consoli, Gianluca Festini, Giuseppe Longo, Agostino CortelezziPellegrino Musto, Massimo Federico, Antonino Neri, Manlio Ferrarini, Fortunato Morabito

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients. Methods: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549). Results: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P

Original language	English
Pages (from-to)	36-45
Number of pages	10
Journal	European Journal of Haematology
Volume	96
Issue number	1
DOIs	https://doi.org/10.1111/ejh.12545
Publication status	Published - Jan 1 2016

Keywords

Abdominal CT scan
Chronic lymphocytic leukemia
Clinical monoclonal B-cell lymphocytosis
Early stage
Prognosis

ASJC Scopus subject areas

Hematology

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Gentile, M., Cutrona, G., Molica, S., Ilariucci, F., Mauro, F. R., Di Renzo, N., Di Raimondo, F., Vincelli, I., Todoerti, K., Matis, S., Musolino, C., Fabris, S., Lionetti, M., Levato, L., Zupo, S., Angrilli, F., Consoli, U., Festini, G., Longo, G., ... Morabito, F. (2016). Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study. European Journal of Haematology, 96(1), 36-45. https://doi.org/10.1111/ejh.12545

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients : Results of the multicenter O-CLL1-GISL study. / Gentile, Massimo; Cutrona, Giovanna; Molica, Stefano; Ilariucci, Fiorella; Mauro, F. R.; Di Renzo, Nicola; Di Raimondo, Francesco; Vincelli, Iolanda; Todoerti, Katia; Matis, Serena; Musolino, Caterina; Fabris, Sonia; Lionetti, Marta; Levato, Luciano; Zupo, Simonetta; Angrilli, F.; Consoli, Ugo; Festini, Gianluca; Longo, Giuseppe; Cortelezzi, Agostino; Musto, Pellegrino; Federico, Massimo; Neri, Antonino; Ferrarini, Manlio; Morabito, Fortunato.

In: European Journal of Haematology, Vol. 96, No. 1, 01.01.2016, p. 36-45.

Research output: Contribution to journal › Article › peer-review

Gentile, M, Cutrona, G, Molica, S, Ilariucci, F, Mauro, FR, Di Renzo, N, Di Raimondo, F, Vincelli, I, Todoerti, K, Matis, S, Musolino, C, Fabris, S, Lionetti, M, Levato, L, Zupo, S, Angrilli, F, Consoli, U, Festini, G, Longo, G, Cortelezzi, A, Musto, P, Federico, M, Neri, A, Ferrarini, M & Morabito, F 2016, 'Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study', European Journal of Haematology, vol. 96, no. 1, pp. 36-45. https://doi.org/10.1111/ejh.12545

Gentile, Massimo ; Cutrona, Giovanna ; Molica, Stefano ; Ilariucci, Fiorella ; Mauro, F. R. ; Di Renzo, Nicola ; Di Raimondo, Francesco ; Vincelli, Iolanda ; Todoerti, Katia ; Matis, Serena ; Musolino, Caterina ; Fabris, Sonia ; Lionetti, Marta ; Levato, Luciano ; Zupo, Simonetta ; Angrilli, F. ; Consoli, Ugo ; Festini, Gianluca ; Longo, Giuseppe ; Cortelezzi, Agostino ; Musto, Pellegrino ; Federico, Massimo ; Neri, Antonino ; Ferrarini, Manlio ; Morabito, Fortunato. / Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients : Results of the multicenter O-CLL1-GISL study. In: European Journal of Haematology. 2016 ; Vol. 96, No. 1. pp. 36-45.

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abstract = "Objective: We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients. Methods: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549). Results: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P",

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AU - Cutrona, Giovanna

AU - Molica, Stefano

AU - Ilariucci, Fiorella

AU - Mauro, F. R.

AU - Di Renzo, Nicola

AU - Di Raimondo, Francesco

AU - Vincelli, Iolanda

AU - Todoerti, Katia

AU - Matis, Serena

AU - Musolino, Caterina

AU - Fabris, Sonia

AU - Lionetti, Marta

AU - Levato, Luciano

AU - Zupo, Simonetta

AU - Angrilli, F.

AU - Consoli, Ugo

AU - Festini, Gianluca

AU - Longo, Giuseppe

AU - Cortelezzi, Agostino

AU - Musto, Pellegrino

AU - Federico, Massimo

AU - Neri, Antonino

AU - Ferrarini, Manlio

AU - Morabito, Fortunato

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Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: Results of the multicenter O-CLL1-GISL study

Abstract

Keywords

ASJC Scopus subject areas

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