Prospective Validation of the Italian Alliance Against Cancer Lung Panel in Patients With Advanced Non-Small-Cell Lung Cancer

Vanesa Gregorc, Luca Mazzarella, Chiara Lazzari, Paolo Graziano, Paolo Vigneri, Carlo Genova, Luca Toschi, Gennaro Ciliberto, Laura Bonanno, Angelo Delmonte, Gabriele Bucci, Antonio Rossi, Gianmarco Motta, Simona Coco, Arianna Marinello, Simonetta Buglioni, Maria Giulia Cangi, Concetta Di Micco, Alessandro Bandiera, Silvia BonfiglioLorenza Pecciarini, Alessandro Guida, Arnaud Ceol, Gianmaria Frige', Ruggero De Maria, Pier Giuseppe Pelicci

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The deeper knowledge of non-small-cell lung cancer (NSCLC) biology and the discovery of driver molecular alterations have opened the era of precision medicine in lung oncology, thus significantly revolutionizing the diagnostic and therapeutic approach to NSCLC. In Italy, however, molecular assessment remains heterogeneous across the country, and numbers of patients accessing personalized treatments remain relatively low. Nationwide programs have demonstrated that the creation of consortia represent a successful strategy to increase the number of patients with a molecular classification.

PATIENTS AND METHODS: The Alliance Against Cancer (ACC), a network of 25 Italian Research Institutes, has developed a targeted sequencing panel for the detection of genomic alterations in 182 genes in patients with a diagnosis of NSCLC (ACC lung panel). One thousand metastatic NSCLC patients will be enrolled onto a prospective trial designed to measure the sensitivity and specificity of the ACC lung panel as a tool for molecular screening compared to standard methods.

RESULTS AND CONCLUSION: The ongoing trial is part of a nationwide strategy of ACC to develop infrastructures and improve competences to make the Italian research institutes independent for genomic profiling of cancer patients.

Original languageEnglish
Pages (from-to)e637-e641
JournalClinical Lung Cancer
Issue number4
Publication statusPublished - Jul 2021


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