Prospects for cutaneous wound healing in ageing skin. A working hypotesis: Chitosan and ceramides

M. G. Tucci, M. Mattioli Belmonte, R. Muzzarelli, G. Ricotti, A. Giacchetti, G. Biagini

Research output: Contribution to journalArticlepeer-review


In elderly people the cutis is characterised by structural fragility due to causes ranging from the thinning of the lipid-epithelial stratum to reduced dermal vascularisation, in particular, reduction in the content of all lipids - due mainly to sphingolipids and ceramides, especially at the level of the stratum corneum - and in the extracellular matrix because of greater degradation and reduced synthesis. We set out to investigate the functional implications of a molecular association of lipopolysaccarides applied to elderly people wound healing with a view to re-establishing the cutaneous microenvironment which in these subjects is unbalanced and at risk. Water-soluble chitosans in the class of N-carboxyalkyl chitosans possess antimicrobial activity including candidacidal activity, and regenerated chitins and water-soluble chitosans are being used as wound dressings which facilitate the formation of new, ordered tissue. Based on these observations, the combined action of ceramides and chitosan appears to meet the requirements of the elderly, and may constitute in vivo a natural association capable of improving the cutaneous microenvironment.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalJournal of Applied Cosmetology
Issue number2
Publication statusPublished - 1998


  • Ceramides
  • Chitosan
  • Wound healing

ASJC Scopus subject areas

  • Dermatology


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