PROSTACYCLIN-LIKE ACTIVITY AND BLEEDING IN RENAL FAILURE

G. Remuzzi, G. Mecca, A. E. Cavenaghi, M. B. Donati, G. De Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Specimens of venous tissue from three normal subjects and three patients with renal failure and very prolonged bleeding-times showed prostacyclin-like activity (inhibition of platelet aggregation) during incubation at room temperature. The specimens from all three uræmic patients showed more prostacyclin-like activity than those from the controls. After repeated washings, when this activity could hardly be detected in the controls, pronounced inhibitory activity was still evident in samples containing venous tissue from the three uræmic patients. These findings may be relevant to the pathogenesis of bleeding in renal failure.

Original languageEnglish
Pages (from-to)1195-1197
Number of pages3
JournalLancet
Volume310
Issue number8050
DOIs
Publication statusPublished - Dec 10 1977

ASJC Scopus subject areas

  • Medicine(all)

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