TY - JOUR
T1 - Prostacyclin reversal of aspirin and indomethacin effects on blood pressure responses to norepinephrine
AU - Fischetti, B.
AU - Carmignani, M.
AU - Marchetti, P.
AU - Ranelletti, F. O.
AU - Caprino, L.
PY - 1980
Y1 - 1980
N2 - Systolic and diastolic blood pressure responses to norepinephrine (NE; 0.125, 0.25, 0.5, 1, 2, and 4 μg/kg, i.v.) were significantly potentiated in anesthetized rats treated with i.v. lysine acetylsalicylate (LASA; 200 mg/kg) or indomethacin (IND; 8 mg/kg). In arterial specimens taken out from these rats, the prostacyclin-like substance production was completely inhibited. Also, the PGI2 infusion (15 ng/kg/min, i.v.) counteracted the LASA or IND induced potentiation of the systolic and diastolic blood pressure responses to NE. These results clearly indicate PGI2, and not PGE2, as the prostaglandin mainly involved in the modulation of systemic vascular reactivity to noradrenergic stimulation.
AB - Systolic and diastolic blood pressure responses to norepinephrine (NE; 0.125, 0.25, 0.5, 1, 2, and 4 μg/kg, i.v.) were significantly potentiated in anesthetized rats treated with i.v. lysine acetylsalicylate (LASA; 200 mg/kg) or indomethacin (IND; 8 mg/kg). In arterial specimens taken out from these rats, the prostacyclin-like substance production was completely inhibited. Also, the PGI2 infusion (15 ng/kg/min, i.v.) counteracted the LASA or IND induced potentiation of the systolic and diastolic blood pressure responses to NE. These results clearly indicate PGI2, and not PGE2, as the prostaglandin mainly involved in the modulation of systemic vascular reactivity to noradrenergic stimulation.
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U2 - 10.1016/S0031-6989(80)80088-9
DO - 10.1016/S0031-6989(80)80088-9
M3 - Article
C2 - 6994128
AN - SCOPUS:0018865099
VL - 12
SP - 319
EP - 328
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 4
ER -